{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:17:50Z","timestamp":1776878270118,"version":"3.51.2"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to analyze residual\/recurrent disease and its risk factors as well as the appropriate frequency of follow-up cytology and human papillomavirus (HPV) tests after loop electrosurgical excision procedure (LEEP) for CIN2\/3. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We retrospectively analyzed 835 patients with CIN2\/3 who were treated with LEEP. Post-LEEP follow-up was performed using liquid-based cytology tests or\/and HPV DNA tests. Residual\/recurrent disease was defined as biopsy-proven CIN2\/3; cervical cancer and vulval intraepithelial neoplasia were not considered as residual\/recurrent cases. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; CIN2\/3 was detected in 19\/835 (2.3%) patients during follow-up. In multivariate logistic regression analysis, post-treatment CIN2\/3 was significantly more likely in cases of preoperative HPV-16 infection (OR 8.208, 95% CI 1.514-44.489), positive excision margins (OR 4.811, 95% CI 1.154-20.258), persistent HPV infection (OR 5.231, 95% CI 1.141-23.976) and abnormal liquid-based cytology tests at 3-month follow-up (OR 16.495, 95% CI 3.689-73.764). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Some factors, such as HPV-16 infection, positive excision margins, persistent HPV infection and abnormal liquid-based cytology tests at 3-month follow-up, appeared to be strong risk factors for residual\/recurrent CIN2\/3 after LEEP. Therefore, patients who undergo LEEP for CIN and follow-up 3 months after LEEP should be assessed for these high-risk factors.<\/jats:p>","DOI":"10.1159\/000437423","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T21:01:30Z","timestamp":1441227690000},"page":"296-301","source":"Crossref","is-referenced-by-count":21,"title":["Analysis of Residual\/Recurrent Disease and Its Risk Factors after Loop Electrosurgical Excision Procedure for High-Grade Cervical Intraepithelial Neoplasia"],"prefix":"10.1159","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-2295","authenticated-orcid":false,"given":"Jin","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoning","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70103-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03380.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.050"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000209214"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2010.01280.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70283-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318287d329"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21604"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39363.471806.BE"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00246-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.2012.07.006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2012.23.4.217"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01063.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2013.09.004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000371760"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.97152"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.063"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji187"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.10.011"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437423","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:40:04Z","timestamp":1745430004000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000437423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,3]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,7,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000437423","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,3]]}}}