{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:11:57Z","timestamp":1762866717271,"version":"3.40.5"},"reference-count":45,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Of the 35 million human immunodeficiency virus (HIV)-positive patients worldwide, 10-40% are coinfected with chronic hepatitis C virus (HCV). Compared to HCV-monoinfected patients, those coinfected experience decreased spontaneous HCV clearance, accelerated liver fibrosis, and a decreased response to anti-HCV therapy. We conducted a meta-analysis to estimate the efficacy of treating acute HCV in HIV-positive patients with peginterferon and ribavirin combination therapy. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Two authors independently searched MEDLINE and EMBASE (2014) for English articles, and reviewed bibliographies and abstracts from major liver and HIV conferences (2011-2013). Original studies featuring at least 10 treatment-naive, HIV-positive adults infected with acute HCV and treated with peginterferon and ribavirin were included. Analyses were calculated using a random-effects model. Heterogeneity was assessed using the Cochrane Q test (p &lt; 0.05) and the I&lt;sup&gt;2&lt;\/sup&gt; statistic (&gt;50%). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; From 12 studies (450 patients), the pooled sustained virological response (SVR) was 71.4% (95% CI 64.7-77.4; Q statistic = 22.20, p = 0.023, I&lt;sup&gt;2&lt;\/sup&gt; = 50.44). The rapid virological response (RVR; 7 studies, 196 patients) was 47.4% (95% CI 40.6-54.7), and the early virological response (EVR; 9 studies, 283 patients) was 82.8% (95% CI 67.0-92.0). The probability of an SVR was 93.1% (95% CI 84.9-97.0) in those who obtained an RVR (6 studies, 82 patients) and 85.9% (95% CI 78.7-91.0) if an EVR (7 studies, 168 patients) was reached. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Peginterferon with ribavirin is an effective option for treating acute HCV in HIV-positive patients, especially if they achieve an RVR or an EVR.<\/jats:p>","DOI":"10.1159\/000437427","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T21:01:21Z","timestamp":1443128481000},"page":"242-249","source":"Crossref","is-referenced-by-count":10,"title":["Treatment of Acute Hepatitis C Infection with Pegylated Interferon and Ribavirin in Patients Coinfected with Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"58","author":[{"given":"Bing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nghia H.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany E.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Yip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid S.","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen A.","family":"Lutchman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-4989","authenticated-orcid":false,"given":"Mindie H.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1086\/425360"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.03.026"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.01.020"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.11.004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328330ed24"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212313272702"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2005.00651.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.4.450"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290311"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/PL00004151"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis538"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir854"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004888.pub2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03294.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12524"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70149-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7734"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-2-201307160-00654"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu012"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2006.00802.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01167.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011232"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-014-0371-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283553719"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.38"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1187"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1843"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(12)63749-4"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-16-5-237"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000200541.40633.56"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000174930.64145.a9"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000226956.02719.fd"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.08.020"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2011.0289"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283480144"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23959"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1177\/0956462412472317"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.019"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit799"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.1328"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.025"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283036cac"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12272"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1501"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/437427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:40:06Z","timestamp":1745430006000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000437427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000437427","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5128486","asserted-by":"subject"}]},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"type":"print","value":"0300-5526"},{"type":"electronic","value":"1423-0100"}],"subject":[],"published":{"date-parts":[[2015]]}}}