{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:10:25Z","timestamp":1790813425050,"version":"4.1.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Background:<\/i><\/b> End-tidal breath carbon monoxide (ETCOc) levels correlate with catabolism of heme, but until recently, this measurement was not readily available for application to neonatology practice. <b><i>Objectives:<\/i><\/b> We performed a prospective, multihospital, test-of-concept study where ETCOc was measured during the birth hospitalization of neonates with a total bilirubin (TB) value >75th percentile on the Bhutani bilirubin nomogram. This was done to test the feasibility and ease of use of this new device. <b><i>Methods:<\/i><\/b> Neonates with an elevated ETCOc (with a >95th percentile reference interval previously established) were labeled as having \u2018hemolytic jaundice'. We recommended a follow-up TB check <24 h after hospital discharge to these families. <b><i>Results:<\/i><\/b> One hundred and fifteen neonates were eligible for the study, the parents of 103 provided consent, and measurements were obtained for 100. Sixty-three had normal and 37 had elevated ETCOc values. By means of a direct antiglobulin test (DAT; Coombs), 11 of these 37 were found positive for ABO hemolytic disease; the remaining 26 had other etiologies. Thirty-six of the 37 with an elevated ETCOc had repeat TB monitoring <24 h after discharge home. None of the 100 were rehospitalized for jaundice treatment compared with a rate of 2.99 rehospitalizations per 100 control neonates who had a TB value >75th percentile (p = 0.079). <b><i>Conclusion:<\/i><\/b> ETCOc measurement is a feasible means of assessing hemolysis in jaundiced neonates during the birth hospitalization. When hemolysis is identified, parents are likely to comply with instructions to bring the infant for a TB checkup <24 h after discharge home.<\/jats:p>","DOI":"10.1159\/000438482","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T21:01:32Z","timestamp":1442955692000},"page":"1-5","source":"Crossref","is-referenced-by-count":39,"title":["Measuring End-Tidal Carbon Monoxide of Jaundiced Neonates in the Birth Hospital to Identify Those with Hemolysis"],"prefix":"10.1159","volume":"109","author":[{"given":"Robert D.","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Malleske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane K.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie L.","family":"Baer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-2940","authenticated-orcid":false,"given":"Josef T.","family":"Prchal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie E.","family":"Denson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Gerday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberlee A.","family":"Weaver Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JuLyn G.","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.66"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.02.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1315973"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.08.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3799"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1030"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-3042"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2014.11.018"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1214"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000357378"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.12.005"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/438482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/438482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:40:38Z","timestamp":1745430038000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000438482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,23]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,1]]},"published-print":{"date-parts":[[2015,12,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000438482","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5128510","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,23]]}}}