{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:34:30Z","timestamp":1791646470177,"version":"4.3.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background:<\/i><\/b> No prospective study has assessed eradication treatment of early <i>Pseudomonas aeruginosa<\/i> colonisation in bronchiectasis not due to cystic fibrosis (CF). <b><i>Objectives:<\/i><\/b> To evaluate the efficacy of 3 months of nebulised tobramycin after a short course of intravenous antibiotics in the eradication of <i>P. aeruginosa<\/i> and its clinical consequences in non- CF bronchiectasis following initial <i>P. aeruginosa<\/i> infection. <b><i>Methods:<\/i><\/b> A 15-month, single-masked, randomised study including 35 patients was conducted in a tertiary university hospital. Following the isolation of <i>P. aeruginosa<\/i> and a 14-day intravenous treatment with ceftazidime and tobramycin, patients received 300 mg nebulised tobramycin twice daily or placebo during 3 months, and were followed up for 12 months thereafter. <b><i>Results:<\/i><\/b> The median time to recurrence of <i>P. aeruginosa<\/i> infection was higher in the tobramycin than in the placebo group (p = 0.048, log-rank test). At the end of the study 54.5% of the patients were free of <i>P. aeruginosa<\/i> in the tobramycin group and 29.4% in the placebo group. The numbers of exacerbations (p = 0.044), hospital admissions (p = 0.037) and days of hospitalisation (p = 0.034) were lower in the tobramycin than in the placebo group. A global, non-significant trend to improvement in the tobramycin group was observed in most of the other studied parameters on comparing the two groups. Bronchospasm in the tobramycin group was remarkable. <b><i>Conclusions:<\/i><\/b> Our study shows that 3 months of nebulised tobramycin following a short course of intravenous antibiotics may prevent bronchial infection with <i>P. aeruginosa<\/i> and has a favourable clinical impact on non-CF bronchiectasis.<\/jats:p>","DOI":"10.1159\/000438490","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T21:06:56Z","timestamp":1441400816000},"page":"299-305","source":"Crossref","is-referenced-by-count":73,"title":["Eradication Therapy against <b><i>Pseudomonas aeruginosa<\/i><\/b> in Non-Cystic Fibrosis 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