{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:37:47Z","timestamp":1791041867100,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Congenital hyperinsulinism (CHI) is a common cause of hypoglycaemia due to unregulated insulin secretion from pancreatic \u03b2 cells. Medical management includes use of oral diazoxide (a K&lt;sub&gt;ATP&lt;\/sub&gt; channel agonist) and daily injectable octreotide (somatostatin analogue) therapy. However, diazoxide is associated with severe sideeffects such as coarse facies, hypertrichosis and psychosocial\/compliance issues in adolescents. Lanreotide (a long-acting somatostatin analogue) is used in adults with neuroendocrine tumours; however, its role in patients with CHI has not been well described. A 15-year-old girl with diazoxide-responsive CHI had severe hypertrichosis secondary to diazoxide and subsequent compliance\/psychosocial issues. She was commenced on 30 mg of lanreotide every 4 weeks as a deep subcutaneous injection, in an attempt to address these issues. She was able to come off diazoxide treatment 2 months after starting lanreotide. Presently, after 2.5 years of lanreotide treatment, her blood glucose control is stable with complete resolution of hypertrichosis. Clinically significant improvements in the self-reported Paediatric Quality of Life (PedsQL) questionnaire and Strengths and Difficulties Questionnaire (SDQ) were reported after 1 year on lanreotide. No side effects were found, and her liver\/thyroid function and abdominal ultrasound have been normal. We report the first case on the use of lanreotide in an adolescent girl with diazoxide-responsive CHI with significant improvement of quality of life.<\/jats:p>","DOI":"10.1159\/000439131","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T21:01:20Z","timestamp":1442437280000},"page":"355-360","source":"Crossref","is-referenced-by-count":25,"title":["Use of Long-Acting Somatostatin Analogue (Lanreotide) in an Adolescent with Diazoxide-Responsive Congenital Hyperinsulinism and Its Psychological Impact"],"prefix":"10.1159","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-8297","authenticated-orcid":false,"given":"Pratik","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia A.","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"McElroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Hinchey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthil","family":"Senniappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.82.2.F98"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(03)00103-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.064337"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet1046"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-63"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0673"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1296"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s004310100847"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312153092406"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb17263.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00173012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2165\/11318510-000000000-00000"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4158\/EP09184.OR"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000082875"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000341525"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0605"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0874"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1997.tb01545.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.1.7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-11-1440"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:47:11Z","timestamp":1745430431000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000439131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,11,1]]},"published-print":{"date-parts":[[2015,11,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000439131","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}