{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:53Z","timestamp":1745469113472,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background\/Aim:<\/i><\/b> Several methods have been proposed for the better estimation of creatinine clearance (CL<sub>CR<\/sub>) in spinal cord injury (SCI); however, there is no standard method to date. In 2011, Lee-Dang derived an equation to predict CL<sub>CR<\/sub> more accurately, although it was limited by problems inherent in any retrospective study of previously collected data. Thus, a prospective investigation was conducted to evaluate the feasibility of clinical implementation and accuracy of the Lee-Dang method against 5 other methods while controlling sources of bias and confounding. <b><i>Methods:<\/i><\/b> A prospective investigation included 100 patients who met the inclusion criteria, given as follows: a diagnosis of SCI and administration of intravenous aminoglycosides (AG) or vancomycin with their dosing regimen determined by the Lee-Dang equation. The percentage of patients achieving therapeutic goal was determined, and the measured AG and vancomycin drug clearance (mCL<sub>DRUG<\/sub>) values were compared with the results that were estimated from 6 equations. <b><i>Results:<\/i><\/b> The Lee-Dang equation was found to be more accurate, with a smaller magnitude of variance from mCL<sub>DRUG<\/sub> and smaller residuals and bias compared with the alternatives. The Lee-Dang method resulted in >90% of patients achieving the steady state serum concentrations within the pre-defined goal for AG and vancomycin. All other predictive methods grossly overestimated CL<sub>CR<\/sub> and produced markedly lower frequency (<50%) of achieving the goal for both antimicrobials (p < 0.05). <b><i>Conclusion:<\/i><\/b> The prospective data shows that the Lee-Dang method for predicting CL<sub>CR<\/sub> is more accurate relative to the alternative methods in the study population with SCI, thus recommend using the Lee-Dang method for pharmacokinetic dosing of AG and vancomycin in SCI.<\/jats:p>","DOI":"10.1159\/000439186","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T21:01:21Z","timestamp":1441054881000},"page":"66-72","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Analysis of Various Dosing Methods for Aminoglycosides and Vancomycin Therapy in Chronic Spinal Cord Injury Patients"],"prefix":"10.1159","volume":"131","author":[{"given":"Jennifer Pai","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy Thu","family":"Truong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00680.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.1983.4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181c62279"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.82"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/875512250101700201"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.1.93"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sc.1985.8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020199"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.17.5.776"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080434"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.19.2138"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/13.suppl_A.9"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:48:07Z","timestamp":1745430487000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000439186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,9,1]]},"published-print":{"date-parts":[[2015,9,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000439186","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"type":"print","value":"1660-8151"},{"type":"electronic","value":"2235-3186"}],"subject":[],"published":{"date-parts":[[2015]]}}}