{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:30:16Z","timestamp":1780921816908,"version":"3.54.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Pustulosis palmaris et plantaris or palmoplantar pustulosis (PPP) is a refractory pustular eruption of the palms and soles with unknown etiology. In addition to skin lesions, PPP patients may present with severe joint pain and pustulotic arthro-osteitis (PAO), especially of the sternoclavicular joint. PAO is sometimes regarded as a variant of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. Hence, macrolide and tetracycline antibiotics are used for the treatment of PPP with PAO. We report 3 cases of PPP with PAO that did not improve upon administration of macrolide antibiotics with NSAIDs. After administration of cefcapene pivoxil hydrochloride (CFPN-PI), a third-generation cephalosporin, the swelling and sternoclavicular joint pain were promptly reduced and dramatically improved in all 3 cases. We review the conventional antibiotic treatments used currently and propose CFPN-PI as a potentially new therapy for PPP or PPP + PAO.<\/jats:p>","DOI":"10.1159\/000439401","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T21:01:17Z","timestamp":1444165277000},"page":"304-311","source":"Crossref","is-referenced-by-count":15,"title":["Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis"],"prefix":"10.1159","volume":"231","author":[{"given":"Masamoto","family":"Murakami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Namba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Sayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken185"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70233-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12272"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<818::AID-ANR29>3.0.CO;2-G"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.874744"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s003930070059"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/art.10539"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-1849-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/ar2812"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2174\/1874325000903010100"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0274-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04411.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.3.277"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.030"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00124743-199506000-00011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb24734.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb01082.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780351007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/370555a0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/370558a0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1995.tb03435.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00759.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.1109"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1995.tb03948.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:49:15Z","timestamp":1745430555000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000439401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000439401","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}