{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:22:31Z","timestamp":1791332551653,"version":"4.3.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Background:<\/i><\/b> Leptin replacement in patients with leptin gene mutations improves hypogonadotropic hypogonadism. The effects of leptin replacement on luteinizing hormone (LH) secretion in patients with lipodystrophy are unknown. <b><i>Aim:<\/i><\/b> We examined nocturnal LH secretory dynamics on and off exogenous leptin therapy using a 2-period, nonrandomized study that included leptin-na\u00efve and leptin-treated subjects with lipodystrophy. <b><i>Methods:<\/i><\/b> In period 1 (5 days) the leptin-treated group (n = 4) continued leptin; leptin was then withdrawn for the next 14 days (period 2). Leptin-na\u00efve subjects (n = 8) were studied without leptin in period 1 and with leptin replacement in period 2. LH secretory dynamics were assessed (23:00-07:00 h, sampling every 10 min, analyzed by multiparameter deconvolution algorithm) at the end of each period. <b><i>Results:<\/i><\/b> Mean (on vs. off: 5.0 \u00b1 3.1 vs. 3.2 \u00b1 1.3 IU\/l, p = 0.04) and integrated LH concentrations (2,403 \u00b1 1,495 vs. 1,534 \u00b1 642 IU \u00d7 l<sup>-1<\/sup> \u00d7 min<sup>-1<\/sup>, p = 0.04) were higher on leptin therapy. Leptin treatment increased burst mass (9.7\u00b1 15.4 vs. 7.0 \u00b1 11.2 IU\/l, p = 0.03) and tended to nonsignificantly increase LH burst frequency (0.77 \u00b1 0.26 vs. 0.67 \u00b1 0.24 h<sup>-1<\/sup>, p = 0.08). Consequently, leptin therapy increased the pulsatile production rate (64 \u00b1 101 vs. 57 \u00b1 73 IU \u00d7 l<sup>-1<\/sup> \u00d7 8 h<sup>-1<\/sup>, p = 0.01). On leptin, testosterone (507 \u00b1 286 vs. 360 \u00b1 174 ng\/dl, p = 0.09) and estradiol levels (74 \u00b1 36 vs. 29 \u00b1 24 pg\/ml, p = 0.01) were higher in males and females, respectively. <b><i>Conclusions:<\/i><\/b> Leptin increases spontaneous nocturnal LH secretion in patients with lipodystrophy. This is consistent with rodent and in vitro studies showing a direct stimulatory effect (hypothalamic, pituitary or both) of leptin on LH secretion. These novel findings may explicate some of the salutary effects of leptin therapy on the hypothalamic-pituitary-gonadal axis in lipodystrophy.<\/jats:p>","DOI":"10.1159\/000439432","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T21:11:50Z","timestamp":1440450710000},"page":"402-407","source":"Crossref","is-referenced-by-count":21,"title":["Effects of Recombinant Human Leptin (Metreleptin) on Nocturnal Luteinizing Hormone Secretion in Lipodystrophy Patients"],"prefix":"10.1159","volume":"103","author":[{"given":"Brent S.","family":"Abel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4198-1055","authenticated-orcid":false,"given":"Ranganath","family":"Muniyappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica C.","family":"Skarulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Gorden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0480"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1053"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909163411204"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/ng0396-318"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040388"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/43185"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/32911"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.7.3110"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(92)10028-C"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.3.1023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.7.8770941"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.5999"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308767101"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2004.08.021"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15693"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000336003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317490"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-42-6-1031"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-61-1-43"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-6-1136"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2541"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1350"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:49:43Z","timestamp":1745430583000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000439432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,25]]},"references-count":24,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2016,5,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000439432","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5128711","asserted-by":"subject"}]},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,25]]}}}