{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:37:51Z","timestamp":1793504271184,"version":"4.5.0"},"reference-count":39,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T00:00:00Z","timestamp":1448668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T00:00:00Z","timestamp":1448668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We evaluated the hypothesis that in fetuses with congenital heart disease (CHD) there is a correlation between the expected pattern of in utero brain blood supply and the severity of neurodevelopmental impairment. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 58 fetuses with CHD and 58 controls underwent a Doppler ultrasound and fetal MRI at 36-38 weeks. Fetuses with CHD were divided into two functional classes: class A with an expected severe reduction in oxygenated brain blood supply (left outflow tract obstruction and transposition of great vessels) and class B with theoretically near-normal or mildly impaired oxygenated brain blood supply (other CHD). Head biometry and cerebroplacental Doppler were assessed by ultrasound, and brain volumetry, cortical development and metabolism by MRI. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Both class A and B CHD fetuses had significant differences in head biometry, brain perfusion, cortical development and brain metabolism compared with controls. However, there was a significant linear tendency for head biometry, cerebral Doppler, volumes, cortical sulcation and metabolic ratios across the three clinical groups, with signs of more severe brain alterations in type A CHD fetuses. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; All fetuses with CHD showed significant brain developmental changes, but differences were more pronounced in CHD associated with an expected severe reduction in oxygenated blood supply to the brain.<\/jats:p>","DOI":"10.1159\/000439527","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T17:01:12Z","timestamp":1448643672000},"page":"269-278","source":"Crossref","is-referenced-by-count":74,"title":["Severity of Fetal Brain Abnormalities in Congenital Heart Disease in Relation to the Main Expected Pattern of in utero Brain Blood Supply"],"prefix":"10.1159","volume":"39","author":[{"given":"Narc\u00eds","family":"Masoller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Sanz-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e0tima","family":"Crispi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Bennasar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Ega\u00f1a-Ugrinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Bargall\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Mar\u00eda","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Gratac\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00940-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.08.036"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.00996.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.060"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994202"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.2.402"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067393"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.865568"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs281"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/359390"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013051"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.05.045"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1785"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7474"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11147"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14677"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7722"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2677"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1148\/rg.323115120"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.04.008"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300604"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.698"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140104"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000365102"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1990.18.3.165"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08417.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08213.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13373"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.547961"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-002-0404-0"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000209203"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1159\/000209203"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12526"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14714"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.229"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0740254.x"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439527","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:50:25Z","timestamp":1745416225000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000439527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,28]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,5,28]]},"published-print":{"date-parts":[[2016,5,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000439527","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,28]]}}}