{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:26:23Z","timestamp":1761765983317,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2015]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> We recently showed that <smlcap>L<\/smlcap>-Dopa administration is a potent stimulator of cortisol secretion in children with short stature. Herein, we examined whether adrenocorticotropic hormone (ACTH) is implicated in the mechanism by which cortisol is stimulated during the <smlcap>L<\/smlcap>-Dopa test. <b><i>Methods:<\/i><\/b> Nineteen children with short stature who fulfilled the auxological criteria for growth hormone (GH) deficiency and had a subnormal GH response to glucagon stimulation underwent a second GH stimulation test (<smlcap>L<\/smlcap>-Dopa test). Serum GH, cortisol and plasma ACTH were determined at baseline and every 30 min up to 120 min after oral <smlcap>L<\/smlcap>-Dopa administration. Peak values of GH >10 ng\/ml, cortisol >18 \u03bcg\/dl and ACTH >52 pg\/ml were considered as normal response. <b><i>Results:<\/i><\/b> Normal response rates were 10.5% (2\/19) for GH, 94.7% (18\/19) for cortisol and 68.4% (13\/19) for ACTH. Among the children with a normal response in ACTH, its concentration increased from a basal value (mean \u00b1 standard deviation) of 23.3 \u00b1 9.6 to 290.3 \u00b1 221 pg\/ml, almost always 90-120 min after <smlcap>L<\/smlcap>-Dopa administration. Mean peak cortisol was 36.2 \u00b1 9.1 \u03bcg\/dl, and it peaked almost simultaneously with ACTH. <b><i>Conclusion:<\/i><\/b> Our data suggest a stimulatory effect of the dopaminergic system on the hypothalamic-pituitary-adrenal axis.<\/jats:p>","DOI":"10.1159\/000439532","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T02:35:17Z","timestamp":1442975717000},"page":"319-322","source":"Crossref","is-referenced-by-count":11,"title":["<smlcap>L<\/smlcap>-Dopa Stimulates Cortisol Secretion through Adrenocorticotropic Hormone Release in Short Children"],"prefix":"10.1159","volume":"84","author":[{"given":"Chrisanthi","family":"Marakaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios T.","family":"Papadimitriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleanthis","family":"Kleanthous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios","family":"Papadimitriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.02.027"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000357268"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb19688.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.5.7956940"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00167.2004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002642"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/endo-120-3-1201"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001933"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050142"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.2067"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:50:27Z","timestamp":1745430627000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000439532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,11,1]]},"published-print":{"date-parts":[[2015,11,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000439532","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2015]]}}}