{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:24:08Z","timestamp":1789932248306,"version":"4.0.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis Extra"],"abstract":"<b><i>Background:<\/i><\/b> Due to the lack of specific diagnostic markers, the diagnosis of cancer-related stroke strongly depends on its phenotype. Distinct DWI lesion patterns with involvement of multiple vascular territories have been reported repeatedly in cancer-related stroke but have not been addressed in detail in a selected cohort of prospectively recruited cancer patients with emphasis on hypercoagulable conditions. <b><i>Patients and Methods:<\/i><\/b> Ischemic stroke patients with known malignant cancer activity, laboratory evidence of strong plasmatic hypercoagulation (D-dimer levels >3 \u00b5g\/ml) and without competing stroke etiologies according to the recently introduced ASCOD (A - atherosclerosis, S - small vessel disease, C - cardiac pathology, O - other cause, and D - dissection) classification of evidence-rated etiology of stroke subtypes were included in the analysis. Cerebral MRI on admission was reviewed with respect to ischemic lesion patterns. <b><i>Results:<\/i><\/b> Thirty-two patients met the inclusion criteria. The mean D-dimer levels were 15.39 \u00b5g\/ml (\u00b110.84). Acute infarction in \u22652 vascular territories was present in 27\/32 (84%) patients. (Micro-) embolic scattering of infarction was present in 25\/32 (78%) patients. Evidence for previous, potentially oligosymptomatic infarction was found in 16 (50%) patients, demonstrated by the additional presence of subacute or chronic ischemic lesions. <b><i>Conclusion:<\/i><\/b> When excluding competing embolic and nonembolic stroke etiologies, the pattern of scattered DWI lesions in multiple vascular supply territories strongly dominates the phenotype of cancer-related stroke. Additionally, evidence of recurrent infarction is frequent in this cohort of patients. This is not only important for the diagnosis of cancer-related stroke itself but may prove helpful for the identification of cancer-related stroke patients with unknown malignancy at the time of stroke manifestation and evaluation of strategies for secondary prevention.<\/jats:p>","DOI":"10.1159\/000439549","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T22:01:24Z","timestamp":1446156084000},"page":"139-145","source":"Crossref","is-referenced-by-count":37,"title":["DWI Lesion Patterns in Cancer-Related Stroke - Specifying the Phenotype"],"prefix":"10.1159","volume":"5","author":[{"given":"Christopher Jan","family":"Schwarzbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Fatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Eisele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne D.","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Hennerici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198501000-00002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.615534"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.658625"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.2.53"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.8.1562"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1323"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2633-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00621-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000352050"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6325-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.571356"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12124"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22050"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000810"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.12.1730"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088283"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-1011-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006650.pub3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006649.pub5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7351"}],"container-title":["Cerebrovascular Diseases Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439549","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:50:36Z","timestamp":1745430636000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000439549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,30]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000439549","archive":["Portico"],"relation":{},"ISSN":["1664-5456"],"issn-type":[{"value":"1664-5456","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,30]]}}}