{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:46:01Z","timestamp":1778687161789,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; To evaluate the relationship between plasma hydrogen sulfide (H&lt;sub&gt;2&lt;\/sub&gt;S) and cardiovascular risk markers, including pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in chronic hemodialysis (CHD) patients and further investigate the underlying cardiovascular protection mechanism of H&lt;sub&gt;2&lt;\/sub&gt;S. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; CHD patients, 113 of them, were studied. Plasma H&lt;sub&gt;2&lt;\/sub&gt;S was measured through zinc acetate reaction. cPKC\u03b2II membrane translocation and phosphorylation of Akt were detected by western blot. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Lower plasma H&lt;sub&gt;2&lt;\/sub&gt;S level in CHD patients was predictor of an increased PP, LVMI and IMT. Patients with lower H&lt;sub&gt;2&lt;\/sub&gt;S had a lower survival at the end of the study. H&lt;sub&gt;2&lt;\/sub&gt;S was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. CHD patients with lower H&lt;sub&gt;2&lt;\/sub&gt;S showed an increase of cPKC\u03b2II activation, but phosphorylation of Akt decreased. The level of VCAM-1 and ICAM-1 increased significantly. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Lower plasma H&lt;sub&gt;2&lt;\/sub&gt;S in CHD patients is associated with cardiovascular risk factors and mortality, which may be mediated by the cPKC\u03b2II\/Akt pathway and further VCAM-1\/ICAM-1 upregulation.<\/jats:p>","DOI":"10.1159\/000439580","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T21:01:26Z","timestamp":1444165286000},"page":"260-269","source":"Crossref","is-referenced-by-count":21,"title":["Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKC\u03b2II\/Akt Pathway in Chronic Hemodialysis Patients"],"prefix":"10.1159","volume":"40","author":[{"given":"Su-Juan","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-6911","authenticated-orcid":false,"given":"Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,10,7]]},"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439580","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/439580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:51:13Z","timestamp":1745430673000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000439580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,10,1]]},"published-print":{"date-parts":[[2015,10,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000439580","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}