{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:05Z","timestamp":1791252845549,"version":"4.1.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T00:00:00Z","timestamp":1445644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T00:00:00Z","timestamp":1445644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Ovarian torsion is a common cause of local ischemic damage, reduced follicular activity and infertility. Platelet-rich plasma (PRP) contains growth factors with demonstrated cytoprotective properties; so we evaluated PRP efficacy in a rat ischemia\/reperfusion (I\/R) model. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Sixty adult female Sprague-Dawley albino rats were randomly assigned to 6 groups of 8 animals each: Sham, Ischemia, I\/R, Sham + PRP, I + PRP and I\/R + PRP; and the remaining 12 used to prepare PRP. Ischemia groups were subjected to bilateral adnexal torsion for 3 h, while I\/R and I\/R + PRP groups received subsequent detorsion for 3 h. Intraperitoneal PRP was administered 30 min prior to ischemia (Ischemia + PRP) or reperfusion (I\/R + PRP). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Total oxidant status (TOS), oxidative stress index (OSI) and total ovarian histopathological scores were higher in Ischemia and I\/R groups than in the Sham group (p &lt; 0.05). PRP decreased mean TOS, OSI and histopathological scores in I + PRP and I\/R + PRP groups compared to the corresponding Ischemia and I\/R groups (p &lt; 0.001). There was a strong correlation between total histopathological score and OSI (r = 0.877, p &lt; 0.001). Peritoneal vascular endothelial growth factor was significantly higher in PRP-treated groups than corresponding untreated groups (p &lt; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; PRP is effective for the prevention of ischemia and reperfusion damage in rat ovary.<\/jats:p>","DOI":"10.1159\/000440617","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T22:52:41Z","timestamp":1445640761000},"page":"225-231","source":"Crossref","is-referenced-by-count":55,"title":["Protective Effect of Platelet Rich Plasma on Experimental Ischemia\/Reperfusion Injury in Rat Ovary"],"prefix":"10.1159","volume":"81","author":[{"given":"Murat","family":"Bakacak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet 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