{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:42:25Z","timestamp":1774057345038,"version":"3.50.1"},"reference-count":39,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T00:00:00Z","timestamp":1445385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T00:00:00Z","timestamp":1445385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; This study measured the serum levels of complement component (C)3a and C5a and the placental expressions of C3a receptor (R) and C5aR to determine a potential correlation with circulating angiotensin II type 1 (AT1) receptor agonistic autoantibody (AT1-AA) in severe pre-eclampsia. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 118 women were recruited and divided into 2 groups: the control group (normotensive preterm pregnancies, n = 66) and severe pre-eclampsia group (n = 52). Levels of C3a, C5a and AT1-AA in serum were measured by enzyme-linked immunosorbent assay and C3aR and C5aR in placenta by Western blotting. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Levels of C3a, C5a and AT1-AA in serum from the severe pre-eclampsia group were significantly higher than in controls (p &lt; 0.05). Placental expression of C3aR and C5aR in the pre-eclampsia group was lower than that in controls (p &lt; 0.05). There were significant positive correlations between levels of C3a, C5a and AT1-AA in serum from the pre-eclampsia group (p &lt; 0.05). In contrast, there was no correlation between C3aR and C5aR in the placenta and AT1-AA in serum in the pre-eclampsia group (p &gt; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Increased C3a, C5a and AT1-AA in the serum provide indirect evidence that AT1-AA-mediated activation contributes to activate complement, which is a key mechanism underlying the pathogenesis of severe pre-eclampsia.<\/jats:p>","DOI":"10.1159\/000440651","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T17:05:45Z","timestamp":1445447145000},"page":"28-33","source":"Crossref","is-referenced-by-count":14,"title":["Complement Split Products C3a\/C5a and Receptors: Are They Regulated by Circulating Angiotensin II Type 1 Receptor Autoantibody in Severe Preeclampsia?"],"prefix":"10.1159","volume":"81","author":[{"given":"Yuanhua","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62259-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20110672"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.03.010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000363294"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004953"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261503"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0737com"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-297648"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.11.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061022"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5452.498"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.200116116"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00321-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903301009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.01.021"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.34.20231"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01390-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1923"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0442-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.3391"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1586\/eci.11.56"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.141465"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.10.005"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.06.011"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4106"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2007.06695.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.044"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fc3afa"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2012.11.006"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.02.035"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1385\/IR:32:1-3:187"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2012.04.005"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217991110"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1161\/hy0102.100778"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.08.003"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000182677.89816.38"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142855.68398.3A"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1373.1999.d01-139.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.191817"}],"container-title":["Gynecologic 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