{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:23:52Z","timestamp":1756189432040,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Ultrasound-guided fine-needle aspiration (UG-FNA) is utilized to sample axillary lymph nodes in breast cancer patients. Diagnostic sensitivity is good but few data exist regarding the causes of false-negative results. &lt;b&gt;&lt;i&gt;Study Design:&lt;\/i&gt;&lt;\/b&gt; Fifty-four UG-FNAs of sentinel lymph nodes with histologic follow-up were identified. Gross and radiographic lymph node size, the percentage replaced by carcinoma and the cortical thickness were correlated with false-negative rates. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Thirty-seven aspirates were negative, 5 of these being false-negative (9%). True-positive lymph nodes averaged 1.3 cm in dimension while false-negatives averaged 0.92 cm. Percentage involvement by carcinoma for true-positive FNAs averaged 69% while false-negatives averaged 25%. Cortical thickness averaged 5.6 mm in true-positive FNAs but 2.9 mm in false-negatives. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; A relationship exists between lymph node size and the likelihood of a false-negative FNA. Lymph nodes &lt;1.2 cm have a higher incidence of false-negative results. Lymph nodes with &lt;30% involvement demonstrated a higher percentage of false-negatives than those with &gt;30% replacement. Sentinel lymph nodes &lt;1 cm appear to be relatively poor candidates for UG-FNA. Lymph nodes with a cortical thickness &lt;3.5 mm are more often associated with a false-negative result than nodes with a thicker cortex.<\/jats:p>","DOI":"10.1159\/000440797","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T21:01:21Z","timestamp":1443646881000},"page":"311-314","source":"Crossref","is-referenced-by-count":22,"title":["Determinants of False-Negative Fine-Needle Aspirates of Axillary Lymph Nodes in Women with Breast Cancer: Lymph Node Size, Cortical Thickness and Hilar Fat Retention"],"prefix":"10.1159","volume":"59","author":[{"given":"D. Eric","family":"Ewing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester J.","family":"Layfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Travis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1245\/s10434-010-1347-y"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1111\/j.1440-1673.2006.01545.x"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1002\/cncr.23344"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1007\/s10549-006-9355-0"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1111\/j.1445-2197.2009.05090.x"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1002\/cncy.20152"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1002\/cncy.21384"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1002\/bjs.8738"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016\/j.jamcollsurg.2011.09.024"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1245\/s10434-009-0421-9"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1148\/rg.27si075502"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440797","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:53:28Z","timestamp":1745430808000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000440797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,8,1]]},"published-print":{"date-parts":[[2015,10,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000440797","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2015]]}}}