{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:44:13Z","timestamp":1766087053805,"version":"3.40.5"},"reference-count":8,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T00:00:00Z","timestamp":1447459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T00:00:00Z","timestamp":1447459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Objective:<\/i><\/b> The aim of this study was to investigate the frequency of the <i>LCT<\/i>*<i>-13910C>T<\/i> polymorphism associated with a high expression of lactase in the small intestine during adulthood, and to infer the lactase persistence and adult-type hypolactasia phenotypes among Euro-Brazilians and Mennonites from South Brazil. <b><i>Materials and Meth<\/i><\/b><b><i> ods:<\/i><\/b> A sequence-specific PCR method to genotype the <i>LCT<\/i>*<i>-13910C>T<\/i> polymorphism in 292 Euro-Brazilians and 151 Mennonites (a group with European ancestry and a long history of endogamy) was developed. Using an exact test of population differentiation, the genotype and allele frequency between these and other Brazilian populations were compared. <b><i>Results:<\/i><\/b> The frequency of <i>-13910<\/i>*<i>T<\/i> was significantly higher among the Mennonites when compared to the Euro-Brazilian cohort (0.63 vs. 0.33, p < 0.000001). Accordingly, Mennonites had a higher prevalence of the lactase persistence genotype (88.1 vs. 55.5%, p < 0.000001). The distribution of -<i>13910<\/i>*<i>T<\/i> differed between Mennonites and all other Brazilian groups (p < 0.0001). The Euro-Brazilians from Curitiba displayed differences when compared to all other Brazilian groups (p < 0.0001), even to Euro-Brazilians from a different geographic region (p = 0.0003), but were similar to those from Porto Alegre (p = 0.2). <b><i>Conclusion:<\/i><\/b> Differences in the <i>-13910<\/i>*<i>T-<\/i>associated lactase persistence distribution among Euro-Brazilian groups reflect the ancestry and admixture of each particular group and should be considered for adult-type hypolactasia screening.<\/jats:p>","DOI":"10.1159\/000440807","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T22:01:35Z","timestamp":1447452095000},"page":"18-20","source":"Crossref","is-referenced-by-count":6,"title":["The Frequency of the <b><i>LCT<\/i><\/b>*<b><i>-13910C>T<\/i><\/b> Polymorphism Associated with Lactase Persistence Diverges among Euro-Descendant Groups from Brazil"],"prefix":"10.1159","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7094-2293","authenticated-orcid":false,"given":"Stefanie Epp","family":"Boschmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica Beate","family":"Boldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il\u00edada Rainha","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza","family":"Petzl-Erler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iara Jose","family":"Messias-Reason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1993.tb01593.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0593-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/ng826"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.077404"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017063"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-8-46"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046520"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9770-4"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440807","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:53:32Z","timestamp":1745430812000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000440807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,14]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000440807","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2015,11,14]]}}}