{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:19Z","timestamp":1745469139196,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;Background: &lt;\/b&gt;Pharmacodynamic studies and data concerning adaptation of thyroid substitution in patients with substituted hypothyroidism during plasma exchange (PE) is not available. &lt;b&gt;Case Report: &lt;\/b&gt;We measured TSH, fT&lt;sub&gt;3&lt;\/sub&gt; and fT&lt;sub&gt;4&lt;\/sub&gt;, total T&lt;sub&gt;4&lt;\/sub&gt;, thyroxin binding globulin (TBG), and albumin before and after 5 PE procedures in a 37-year-old women who underwent PE for a therapy-resistant polyneuropathy. Thyroxin was increased empirically by 8% resulting in a dose of 1.95 \u00b5g\/kg per day. &lt;b&gt;Results: &lt;\/b&gt;Despite larger reductions of total T&lt;sub&gt;4&lt;\/sub&gt; and TBG over a series of 5 PEs (40-50% from baseline), only small reductions of 8% in fT&lt;sub&gt;3&lt;\/sub&gt; and fT&lt;sub&gt;4&lt;\/sub&gt; concentrations were documented with a concomittant increase in TSH level. Changes of fT&lt;sub&gt;4&lt;\/sub&gt;, fT&lt;sub&gt;3&lt;\/sub&gt;, and TSH remained within normal range. &lt;b&gt;Conclusions: &lt;\/b&gt;i) Despite a significant decrease in total thyroid hormone pool following PE, fT&lt;sub&gt;4&lt;\/sub&gt;, fT&lt;sub&gt;3&lt;\/sub&gt;, and TSH concentrations changed only slightly. ii) Based on this observation, a general increase in thyroid replacement therapy before PE cannot be recommended, but considered in case of a high normal TSH level.<\/jats:p>","DOI":"10.1159\/000440822","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T22:01:26Z","timestamp":1449266486000},"page":"45-49","source":"Crossref","is-referenced-by-count":0,"title":["Changes of Thyroid Hormones and Their Binding Proteins during Plasma Exchange for Polyneuropathy in a Patient with Substituted Hypothyroidism due to Hashimoto's Thyroiditis"],"prefix":"10.1159","volume":"43","author":[{"given":"Stefan","family":"Jenni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Adler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Lanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrouz","family":"Mansouri Taleghani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel R.","family":"Christ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2008.09.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12629"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21276"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.2.489"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine1962.25.246"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00571.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03783.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-3-1428"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20200"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00263555"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0353"}],"container-title":["Transfusion Medicine and Hemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:53:44Z","timestamp":1745430824000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000440822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,4]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000440822","archive":["Portico"],"relation":{},"ISSN":["1660-3796","1660-3818"],"issn-type":[{"type":"print","value":"1660-3796"},{"type":"electronic","value":"1660-3818"}],"subject":[],"published":{"date-parts":[[2015,11,4]]}}}