{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:20Z","timestamp":1745469140997,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"10","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Gastric cardia adenocarcinoma (GCA) is a common malignant tumor of the digestive tract with a high incidence in China. Genetic factors such as single nucleotide polymorphisms (SNPs) may contribute to the carcinogenesis of GCA. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a hospital-based case-control study to evaluate the genetic association of functional SNPs with susceptibility to GCA development. A total of 330 GCA cases and 608 controls were recruited for this study. The SNPs OPG rs3102735 T&gt;C and rs2073618 G&gt;C, RANK rs1805034 T&gt;C, and RANKL rs9533156 T&gt;C and rs2277438 A&gt;G were determined using the ligation detection reaction method. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Our findings suggest that RANK rs1805034 T&gt;C is associated with susceptibility to GCA, which is more evident among male patients, elderly patients (\u2265 60 years), smokers, and patients who do not consume alcohol. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Based on our findings, the functional SNP RANK rs1805034 T&gt;C may be an indicator for individual susceptibility to GCA. However, further larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm the current findings.<\/jats:p>","DOI":"10.1159\/000440855","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T21:01:35Z","timestamp":1444078895000},"page":"503-510","source":"Crossref","is-referenced-by-count":3,"title":["RANK rs1805034 T&gt;C Polymorphism Is Associated with Susceptibility to Gastric Cardia Adenocarcinoma in a Chinese Population"],"prefix":"10.1159","volume":"38","author":[{"given":"Wen-Bo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Yong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-Zhong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suo-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Cheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(02)00002-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0044"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20678"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.030031"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-40"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101705"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ng2089"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2352-z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/842452"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:53:58Z","timestamp":1745430838000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000440855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000440855","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"type":"print","value":"2296-5270"},{"type":"electronic","value":"2296-5262"}],"subject":[],"published":{"date-parts":[[2015]]}}}