{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:31:37Z","timestamp":1780497097321,"version":"3.54.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2014]]},"abstract":"<b><i>Background:<\/i><\/b> Quorum sensing (QS), as the basis of bacterial cell-to-cell communication, is a promising approach to reduce the incidence of multidrug resistance. The objective of this study was to search for novel quorum sensing inhibitors from plants and control detrimental infections. <b><i>Methods:<\/i><\/b> The crude extracts of <i>Ficus carica <\/i>and <i>Perilla frutescens<\/i> were examined for their anti-QS properties. Powdered plant samples were treated sequentially with organic solvents of increasing polarity. The extracts of each solvent were concentrated in vacuo to give crude extracts and tested against <i>Chromobacterium violaceum<\/i> CV026 and <i>Pseudomonas aeruginosa<\/i> PA01 especially. Anti-QS activity was measured by quantifying violacein production and swarming motility. <b><i>Results:<\/i><\/b> All extracts of these two plants display anti-QS ability. Interestingly, the extract of <i>F. carica <\/i>with dichloromethane and of <i>P. frutescens <\/i>with MeOH exhibited the most pronounced inhibition of QS activity. <b><i>Conclusions:<\/i><\/b> These two plants can offer bioactive natural products with potential for attenuating pathogens.<\/jats:p>","DOI":"10.1159\/000440946","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T22:52:42Z","timestamp":1445640762000},"page":"379-383","source":"Crossref","is-referenced-by-count":9,"title":["Bacterial Quorum Sensing Inhibition Activity of the Traditional Chinese Herbs, <b><i>Ficus carica <\/i><\/b>L. and <b><i>Perilla frutescens<\/i><\/b>"],"prefix":"10.1159","volume":"60","author":[{"given":"Shiwei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,10,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.21.012704.131001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1021\/ja5110798"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316981110"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1121357"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2005.00001.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.08.049"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004174"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1021\/cb5004288"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.09.004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/0975-9476.131734"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.68.85"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000320185"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-143-12-3703"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000338383"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-008-9215-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000329525"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2010.02993.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2003.09.004"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2405"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:55:10Z","timestamp":1745430910000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000440946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2015,11,1]]},"published-print":{"date-parts":[[2015,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000440946","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}