{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:13:06Z","timestamp":1790374386073,"version":"4.1.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; A total of 12 children with neurofibromatosis type 1 (NF-1) with optic pathway glioma (OPG) and growth hormone (GH) excess are reported to date, but no data exist on the long-term outcome. We describe 2 girls with NF-1 with OPG and GH excess treated with somatostatin analogue (SSa) who maintained a normal GH axis after stopping SSa therapy. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The diagnosis of&lt;b&gt; &lt;\/b&gt;GH excess was established from auxological data, persistently high levels of insulin-like growth factor 1 (IGF-1) and a lack of GH suppression during an oral glucose tolerance test. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Both patients were started on SSa treatment. During treatment, growth deceleration and normal IGF-1 levels were documented. The first case stopped treatment following the development of SSa side effects. The second case interrupted SSa when, closed to her final height, a normal IGF-1 level was documented. While off treatment, both cases maintained normal IGF-1 levels and appropriate growth velocity for their age and development, with normal GH secretion on biochemical testing. Both cases received treatment for central precocious puberty. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; GH excess in NF-1 children with OPG can be reversed and only short-term SSa therapy may be required. The aetiology remains undetermined, but the course suggests a hypothalamic dysfunction.<\/jats:p>","DOI":"10.1159\/000440956","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T21:06:47Z","timestamp":1445461607000},"page":"414-422","source":"Crossref","is-referenced-by-count":21,"title":["Reversible Growth Hormone Excess in Two Girls with Neurofibromatosis Type 1 and Optic Pathway Glioma"],"prefix":"10.1159","volume":"84","author":[{"given":"Patrizia","family":"Bruzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Sani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5494-3010","authenticated-orcid":false,"given":"Assunta","family":"Albanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550010065042"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2009.11.020"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000193070.32369.37"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.4.667"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1970.02100080149020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1985.02140130035025"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91301-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2000.13.S1.841"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.12.933"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn194"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.075937"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80265-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1983.tb13774.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150318"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.81.4.0595"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803701207"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000053188"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01041.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000089486"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.09.013"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000369802"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2165\/11318510-000000000-00000"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-013-0530-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.12.1170"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-2-1103"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-3-17"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015713732717"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03619.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2700"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.150631"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159\/000023308"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/BF00878392"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1244"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2631"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2004.17.5.749"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:55:17Z","timestamp":1745430917000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000440956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000440956","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}