{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:09:20Z","timestamp":1776323360119,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"1-3","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Background:<\/i><\/b> The regional citrate anticoagulation (RCA) induces changes in total (Ca<sup>tot<\/sup>) and ionized (Ca<sup>2+<\/sup>) calcium. As of now, we do not have much information about parallel changes of total (Mg<sup>tot<\/sup>) and ionized (Mg<sup>2+<\/sup>) magnesium. <b><i>Methods:<\/i><\/b> The authors compared changes of Mg<sup>2+<\/sup> and Mg<sup>tot<\/sup> with changes of Ca<sup>2+<\/sup> and Ca<sup>tot<\/sup> in 32 critically ill patients on 4% trisodium citrate (4% TSC) with calcium-free fluids. <b><i>Results:<\/i><\/b> The median continuous venovenous hemodiafiltration balance of Mg<sup>tot<\/sup> was -0.91 (-1.18 to -0.53) mmol\/h compared to the median balance of Ca<sup>tot<\/sup> 0.86 (0.08-1.55) mmol\/h. Postfilter Mg<sup>2+<\/sup> decreased by 68.3% (70.8-65.6) in parallel (r = 0.41, p = 0.03) to decrease of postfilter Ca<sup>2+<\/sup> (by 70.2% (73.0-66.1)) and was significantly related to the postfilter Ca<sup>2+<\/sup> (r = 0.50, p < 0.001). The decrease of prefilter to postfilter Ca<sup>2+<\/sup> correlated to a dosage of 4% TSC per blood flow (r = 0.37, p = 0.04). <b><i>Conclusions:<\/i><\/b> The loss of Mg<sup>tot<\/sup> during RCA is not covered by magnesium concentration in ordinary dialysis\/substitution fluid and may lead to the depletion of total body magnesium. The postfilter Mg<sup>2+<\/sup> is significantly related to the postfilter Ca<sup>2+<\/sup>. Video Journal Club \u201cCappuccino with Claudio Ronco\u201d at http:\/\/www.karger.com\/?doi = 440972.<\/jats:p>","DOI":"10.1159\/000440972","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T21:09:11Z","timestamp":1445288951000},"page":"41-47","source":"Crossref","is-referenced-by-count":25,"title":["Ionized Magnesium and Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy"],"prefix":"10.1159","volume":"41","author":[{"given":"Mychajlo","family":"Zakharchenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Leden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Rul\u00ed\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand","family":"Los","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Brodska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1864-2143","authenticated-orcid":false,"given":"Martin","family":"Balik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,10,20]]},"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440972","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/440972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:55:25Z","timestamp":1745430925000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000440972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,20]]},"references-count":0,"journal-issue":{"issue":"1-3","published-online":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000440972","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,20]]}}}