{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:40:15Z","timestamp":1791322815459,"version":"4.3.1"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Background:<\/i><\/b> Prolonged <i>cis<\/i>-retinoic acid (RA) exposure contributes to premature epiphyseal closure. <i>cis-<\/i>RA is administered in various treatment regimens for pediatric cancers, thus increasing the risk for bone deformities and compromised growth. <b><i>Results:<\/i><\/b> We present a case of premature epiphyseal closure in a 9-year-old female with a history of medulloblastoma and treatment with a multimodal regimen including <i>cis<\/i>-RA. She was subsequently diagnosed with radiation-induced endocrine late effects including hypothyroidism and growth hormone deficiency (GHD). Seven months after initiation of GH therapy, an increased prominence of the wrists and knees combined with a deceleration in growth velocity prompted further evaluation; radiographs revealed bilateral premature closure of the distal femur and proximal tibia growth plates despite normal left wrist bone age. <b><i>Conclusion:<\/i><\/b> High doses of vitamin A and its analogs are linked to premature closure of the lower-extremity growth plates in animals and children. Pediatric brain tumor patients are at increased risk of growth failure due to concurrent radiation-induced GHD, damage to the spinal bones, and <i>cis<\/i>-RA-associated premature closure of the lower-extremity growth plates, with significant reduction in adult stature. A better appreciation of the detrimental effect of <i>cis<\/i>-RA on the growing skeleton is needed to monitor at-risk patients and to provide timely interventions.<\/jats:p>","DOI":"10.1159\/000441140","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T21:18:51Z","timestamp":1444771131000},"page":"69-73","source":"Crossref","is-referenced-by-count":18,"title":["Premature Epiphyseal Closure of the Lower Extremities Contributing to Short Stature after <b><i>cis<\/i><\/b>-Retinoic Acid Therapy in Medulloblastoma: A Case Report"],"prefix":"10.1159","volume":"85","author":[{"given":"Jessica J.","family":"Noyes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean B.","family":"Belasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sogol","family":"Mostoufi-Moab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050490004002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(97)80052-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22839"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.46.Suppl_S113"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050631"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113721"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-007-0604-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.60.815"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nm904"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1471::AID-CNCR1>3.0.CO;2-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0047-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0690"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:57:35Z","timestamp":1745431055000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000441140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000441140","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]}}}