{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:50:29Z","timestamp":1781538629531,"version":"3.54.5"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T00:00:00Z","timestamp":1448668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T00:00:00Z","timestamp":1448668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Rhododendrol, a phenolic compound contained in lightening\/whitening cosmetics, can bind and inhibit tyrosinase and was reported to induce leukoderma in Japan. Only 2% of the cosmetics users are affected, and tacrolimus is effective in treatment of the condition. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To test the hypothesis that the disease is an autoimmune disorder. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Short-term T-cell lines were established using peripheral blood mononuclear cells from 8 patients with human melanoma-associated and tyrosinase-derived synthetic peptides. The effects of rhododendrol on melanoma immunization were also examined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Seven out of 8 patients were positive for HLA-DR4. Both class I- and class II-restricted and tyrosinase peptide-specific T-cell responses were observed. Immunization of mice with rhododendrol-treated and irradiated B16 melanoma cells successfully delayed the growth of melanoma cells in vivo. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Rhododendrol-induced leukoderma is an autoimmune disorder, with rhododendrol as an environmental factor and HLA-DR4 as a genetic factor. Rhododendrol might be effective in treating melanomas.<\/jats:p>","DOI":"10.1159\/000441217","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T22:01:12Z","timestamp":1448661672000},"page":"44-49","source":"Crossref","is-referenced-by-count":7,"title":["T-Cell Responses to Tyrosinase-Derived Self-Peptides in Patients with Leukoderma Induced by Rhododendrol: Implications for Immunotherapy Targeting Melanoma"],"prefix":"10.1159","volume":"232","author":[{"given":"Rie","family":"Takagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12744"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12269"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.14924\/dermatol.124.3125"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.3.873"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.1965"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141511"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32446-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00145.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1981.tb00041.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.90.2.474"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050031"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.441"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2008.40.1.130"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.02.003"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:58:14Z","timestamp":1745431094000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000441217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,28]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000441217","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,28]]}}}