{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:33:15Z","timestamp":1778567595163,"version":"3.51.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T00:00:00Z","timestamp":1445040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T00:00:00Z","timestamp":1445040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to analyze the long-term toxicity and quality of life (QOL) in patients with locally advanced cervical cancer (LACC) treated with chemoradiation [chemotherapy\/radiotherapy (CT\/RT)] or neoadjuvant CT (NACT) followed by radical surgery (RS). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Fifty-nine patients with LACC in remission after treatment with NACT + RS (n = 34) or CT\/RT (n = 25) were interviewed with an Incontinence Impact Questionnaire (IIQ-7), a Quality of Life Questionnaire (EORTC QLQ-C30), and a Quality of Life Questionnaire for Cervical Cancer (EORTC QLQ-CX24) to compare long-term toxicity and QOL. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The mean age was 53 \u00b1 9.8 and 59 \u00b1 11.5 years in the NACT + RS and CT\/RT groups, respectively. Overall, diarrhea and constipation were reported in 15 and 68%, respectively, while bladder complaints and a low level of sexual enjoyment were reported in 36 and 47%, respectively. The NACT + RS patients showed a worse sexual activity (74.71 \u00b1 33.57 vs. 92.06 \u00b1 17.96; p = 0.019) and sexual enjoyment (71.21 \u00b1 23.67 vs. 88.88 \u00b1 21.71; p = 0.040) and more frequently complained of constipation (49.01 \u00b1 34.06 vs. 26.66 \u00b1 31.66; p = 0.013), while CT\/RT patients more frequently suffered from diarrhea (1.96 \u00b1 7.96 vs. 14.66 \u00b1 28.40; p = 0.017). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Many patients treated for LACC have long-term complaints regarding sexual activity and bladder and bowel function. The majority of QOL aspects were similar in the two groups at long-term follow-up. However, diarrhea was more frequent and severe in CT\/RT patients, while constipation was more frequent and severe in NACT + RS patients, and they showed a worse sexual life perception. Larger randomized trials addressing these issues are needed.<\/jats:p>","DOI":"10.1159\/000441226","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T23:45:46Z","timestamp":1445039146000},"page":"29-35","source":"Crossref","is-referenced-by-count":16,"title":["Long-Term Toxicity and Quality of Life in Patients Treated for Locally Advanced Cervical Cancer"],"prefix":"10.1159","volume":"90","author":[{"given":"Piera","family":"Gargiulo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Arenare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina 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