{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:35:04Z","timestamp":1784752504849,"version":"3.55.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Background:<\/i><\/b> In severe alopecia areata (AA), spontaneous recovery is unlikely, and treatment is not standardized. <b><i>Ob<\/i><\/b><b><i>jective:<\/i><\/b> To evaluate the efficacy and safety of methotrexate (MTX) used alone or combined with low- to moderate-dose oral corticosteroids (OC) for treating severe AA (totalis, universalis and severe multifocal). <b><i>Methods:<\/i><\/b> Retrospective monocentric study of all consecutive patients receiving this treatment between 2006 and 2012. Efficacy was defined as achieving a total regrowth of terminal hair. <b><i>Results:<\/i><\/b> 26 patients were included (17 with AA universalis or totalis and 9 with severe multifocal AA). Total regrowth was noted in 15\/26 patients. After 3 months of treatment, hair regrowth >80% was associated with further complete regrowth, and hair regrowth <30% was associated with later treatment failure (p = 0.0014). When treatment was tapered, 11\/15 patients with initial complete efficacy experienced AA relapse. <b><i>Conclusion:<\/i><\/b> MTX combined with low- to moderate-dose OC may be an efficient and well-tolerated treatment for severe AA. However, long-term maintenance treatment is usually required.<\/jats:p>","DOI":"10.1159\/000441250","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T22:01:25Z","timestamp":1452117685000},"page":"242-248","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy and Safety of Methotrexate Combined with Low- to Moderate-Dose Corticosteroids for Severe Alopecia Areata"],"prefix":"10.1159","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4753-9471","authenticated-orcid":false,"given":"Delphine","family":"Anuset","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Perceau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Reguiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1103442"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/304370"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02028.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2174\/187221311795399291"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000085580"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.07.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nature09114"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.12.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.873"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.82123"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.264"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01781.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0138"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.09.010"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.06.031"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10383.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000339341"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142869"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(04)93596-X"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70009-X"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000107626"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000051642"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06608.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000247268"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004413.pub2"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.06.006"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700915"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01135.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb02049.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.01800.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:58:29Z","timestamp":1745431109000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000441250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000441250","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}