{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:52Z","timestamp":1787017912940,"version":"build-2736575974"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Exposure to intrauterine growth retardation (IUGR) can have a negative impact on nephrogenesis resulting in limited fetal kidney development and supporting the hypothesis that IUGR represents a risk for renal function and long-term renal disease. Cystatin-C (Cys-C), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized; what remains is subsequently eliminated in urine. In tubular diseases and in hyperfiltration conditions, it seems reasonable to postulate that Cys-C degradation would decrease, and consequently an increase in its urinary elimination would be observed. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to investigate the urinary excretion of Cys-C simultaneously with the assessment of renal volumes in adequate for gestational age (AGA) and IUGR neonates in order to identify its clinical value in IUGR. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Urinary Cys-C levels were measured using the enzyme immunoassay DetectX\u00ae Human Cystatin C kit in IUGR and AGA neonates. Whole renal and renal cortex volumes&lt;b&gt; &lt;\/b&gt;were assessed with ultrasounds (Vocal II; Software, GE). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Urinary Cys-C levels in IUGR were significantly higher than those found in AGA and were negatively correlated to reduced whole renal and renal cortex volumes. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The increased levels of Cys-C in the urine of neonates with IUGR were significantly associated with reduced renal\/renal cortex volumes, suggesting that Cys-C could be taken as a surrogate of nephron mass. It also could be used as an early biochemical marker to identify IUGR neonates at high risk of developing long-term renal disease and to select patients for monitoring during childhood.<\/jats:p>","DOI":"10.1159\/000441273","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T20:02:19Z","timestamp":1452628939000},"page":"154-160","source":"Crossref","is-referenced-by-count":28,"title":["Increased Urinary Cystatin-C Levels Correlate with Reduced Renal Volumes in Neonates with Intrauterine Growth Restriction"],"prefix":"10.1159","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-8956","authenticated-orcid":false,"given":"Antonella","family":"Barbati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito","family":"Cappuccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Aisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Grasselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosalba","family":"Zamarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Bini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Bellomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Orlacchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Carlo","family":"Di Renzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01799.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00225.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13726.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00018.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2758-y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/136942"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000326341"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0478-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000358480"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S204017441300007X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1042\/bj2680287"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1258\/0004563001901524"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00177-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2006.050"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00740110"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.04.013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.57.s75.5.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1361831"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802360809"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000120681.61201.B4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/346067"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.072"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000187863"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr222"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:58:37Z","timestamp":1745416717000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000441273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000441273","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}