{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:07:02Z","timestamp":1789704422090,"version":"4.0.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aim:&lt;\/i&gt;&lt;\/b&gt; Periocular basal cell carcinomas (pBCC) remain a treatment challenge. Our aim was to retrospectively evaluate the feasibility and efficacy of immunocryosurgery for the treatment of pBCC. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Immunocryosurgery is given in 5-week cycles of daily imiquimod, with cryosurgery on day 14. Patients treated between 1\/1\/2008 and 31\/12\/2014 were included in this study. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Immunocryosurgery was offered to 19 patients. Of these, 16 (i.e. 6 males and 10 females, average age 74.9 years, median tumor diameter 15 mm, range 5-60 mm), with 1 tumor each, were treated. Six tumors (37.5%) were relapses after surgery and 2 were of metatypical histology. All BCC were high risk for recurrence after treatment; 10 tumors had 2 risk factors for relapse, 5 had 3, and 1 had 4. The follow-up period ranged between 3 and 60 months (average 25.6 months). Of the 16 tumors treated, 14 (all with a diameter &lt;40 mm) cleared with immunocryosurgery (total efficacy 87.5%); 7 out of 16 tumors (44%; all with a diameter \u226420 mm) cleared with 1 conventional 5-week immunocryosurgery treatment cycle. Seven additional tumors (including 2 with a diameter &gt;20 mm) required intensified treatment schemes (of up to 10 weeks) for clearance. The 2 tumors that did not clear responded partially and were also the 2 largest ones (diameter 40 and 60 mm). Of the 14 cleared tumors, 2 relapsed during follow-up; 1 cleared with immunocryosurgery. At the last examination during follow-up, 13 out of 16 (81%) patients were in sustained clinical remission. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; For most pBCC, immunocryosurgery is a feasible and efficacious alternative to surgical excision.<\/jats:p>","DOI":"10.1159\/000441491","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T22:01:22Z","timestamp":1447970482000},"page":"17-21","source":"Crossref","is-referenced-by-count":11,"title":["Cryosurgery during Imiquimod (Immunocryosurgery) for Periocular Basal Cell Carcinomas: An Efficacious Minimally Invasive Treatment Alternative"],"prefix":"10.1159","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-1304","authenticated-orcid":false,"given":"Georgios","family":"Gaitanis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris D.","family":"Kalogeropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis D.","family":"Bassukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90161-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.11.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/01676830.2014.950296"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.4430"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03562.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-43939-5_20"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1524"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1609"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.195800"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/01676830490501497"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02367.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.10.008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007041.pub4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-015-0024-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2010.0030"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.178202"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2011.00741.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000432"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1990.tb01916.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.4.453"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.173021"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12441"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:01:35Z","timestamp":1745431295000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000441491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,20]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000441491","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,20]]}}}