{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:07:20Z","timestamp":1775736440003,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>This was a randomized, controlled, parallel-group clinical trial with a blinded evaluator, designed to compare the efficacy and safety of the nail lacquer P-3051 with amorolfine 5% in the treatment of mild-to-moderate toenail onychomycosis. Patients were treated for 48 weeks with P-3051 daily, or twice weekly with amorolfine 5%. Out of 120 evaluable patients, 60 (50.0%) received P-3051 and 60 (50.0%) amorolfine 5%. At baseline, the two groups were homogeneous in terms of race, pathogens, number of affected toenails and severity of the infected target nail area. The statistical superiority of P-3051 versus amorolfine was achieved after 48 weeks (treatment success: 58.3% for P-3051 vs. 26.7% for amorolfine, p &lt; 0.001; complete cure: 35.0% for P-3051 vs. 11.7% for amorolfine, p &lt; 0.001). Mycological cure at week 48 was achieved in all patients treated with P-3051 compared to 81.7% of patients treated with amorolfine (p &lt; 0.001). Moreover, fungal eradication by P-3051 was statistically superior at week 24. The results of this study, and of a previous pivotal study versus the insoluble formulation of ciclopirox 8%, led to consider P-3051 as the gold standard for the topical treatment of mild-to-moderate onychomycosis.<\/jats:p>","DOI":"10.1159\/000441569","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T17:01:18Z","timestamp":1446829278000},"page":"134-140","source":"Crossref","is-referenced-by-count":24,"title":["Ciclopirox 8% HPCH Nail Lacquer in the Treatment of Mild-to-Moderate Onychomycosis: A Randomized, Double-Blind Amorolfine Controlled Study Using a Blinded Evaluator"],"prefix":"10.1159","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-5443","authenticated-orcid":false,"given":"Matilde","family":"Iorizzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Hartmane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andra","family":"Derveniece","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingmars","family":"Mikazans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2015,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00005.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890450124022"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb00722.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107754"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/000155502762064665"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00349.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2004.00968.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.12.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000018488"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04842-14"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04529.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03164.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000353667"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04373.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb00278.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806303182605"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-9-199705010-00007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.109071"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12594"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02382-13"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:02:05Z","timestamp":1745416925000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000441569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,2,1]]},"published-print":{"date-parts":[[2016,2,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000441569","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5241886","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.736007615.793561577","asserted-by":"object"}]},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}