{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:22:57Z","timestamp":1789168977138,"version":"build-2803163510"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;Objective: &lt;\/b&gt;Testing for antibodies against hepatitis B core antigen (anti-HBc) was introduced to detect blood donors suffering from occult hepatitis B infection. Confirmation of specification of reactive results in the anti-HBc screening assay is still a challenge for blood donation services. &lt;b&gt;Methods: &lt;\/b&gt;Two different test strategies for confirmation of specification of reactive anti-HBc tests, one performed in our institute and one suggested by the German authority (Paul-Ehrlich-Institut (PEI)), were compared. The first strategy is based on one supplemental anti-HBc test, the other requires two supplemental anti-HBc tests. &lt;b&gt;Results: &lt;\/b&gt;389 samples from 242 donors were considered. Both test strategies yielded concordant results in 117 reactive samples termed \u2018true-positive' or \u2018specificity confirmed', in 156 reactive samples termed \u2018false-positive' or \u2018specificity not confirmed', and in 99 negative samples. In 17 samples obtained from 11 donors, both test strategies gave discrepant results (\u2018false-positive' but \u2018specificity confirmed'). In 10 of 11 donors, a real HBV infection was very unlikely, one remained unclear. 30 donors considered \u2018false-positive' became negative in all anti-HBc tests after follow-up testing and thus eligible for donor re-entry. &lt;b&gt;Conclusions: &lt;\/b&gt;The test strategy suggested by the PEI yielded no additional information but induced an overestimation of HBV infections and unnecessary look-back procedures. Many anti-HBc-reactive donors can be regained after follow-up testing.<\/jats:p>","DOI":"10.1159\/000441676","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T22:01:26Z","timestamp":1449266486000},"page":"37-43","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of Two Test Strategies for Clarification of Reactive Results for Anti-HBc in Blood Donors"],"prefix":"10.1159","volume":"43","author":[{"given":"David","family":"Juhl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes K.-M.","family":"Knobloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"G\u00f6rg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01276.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0798"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00391.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00128.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.0958-7578.2004.0486.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01396.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03909.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01723.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03736.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03031.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1930-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01522.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.09.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00818.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.05.009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00912.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01844.x"}],"container-title":["Transfusion Medicine and Hemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441676","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:03:03Z","timestamp":1745431383000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000441676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,4]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000441676","archive":["Portico"],"relation":{},"ISSN":["1660-3796","1660-3818"],"issn-type":[{"value":"1660-3796","type":"print"},{"value":"1660-3818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,4]]}}}