{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:21:12Z","timestamp":1782879672339,"version":"3.54.5"},"reference-count":9,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Primary effusion lymphoma (PEL) is a Kaposi's sarcoma-associated herpesvirus (KSHV)-related large B-cell lymphoma often affecting immunocompromised adults. However, several cases in nonimmunocompromised elderly patients have been reported. It usually occurs as a massive, serosal effusion without tumoral masses and lymphadenopathies. The most frequent diagnostic materials are cytological smears, displaying large lymphocytes with variable morphological aspects but with a specific \u2018null-cell' phenotype associated with the expression of KSHV-related latency-associated nuclear antigen. &lt;b&gt;&lt;i&gt;Cases:&lt;\/i&gt;&lt;\/b&gt; We report 2 cases of PEL that occurred in elderly, HIV-uninfected patients. In the first case, an 83-year-old man presented with severe dyspnea of 1 week duration. Radiological images documented pericardial effusion causing cardiac tamponade, without lymphadenopathies and solid masses. In the second case, an HIV-uninfected 94-year-old man was affected by anorexia, fatigue, shortness of breath and nonproductive cough. Radiological studies revealed bilateral pleural effusion, without evidence of abnormal lymphadenopathies and lung and\/or pleural masses. Thoracentesis was immediately performed. Cytological evaluations of pericardial (first case) and pleural (second case) fluid effusion showed anaplastic and immunoblastic lymphocytes, respectively, expressing LCA\/CD45, CD30 and KSHV. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Albeit rare, PEL should be kept in mind in the diagnostic algorithm of serosal cytological evaluation in elderly HIV-uninfected patients.<\/jats:p>","DOI":"10.1159\/000441938","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T22:01:27Z","timestamp":1447884087000},"page":"425-428","source":"Crossref","is-referenced-by-count":8,"title":["Primary Effusion Lymphoma: Cytological Diagnosis of a Rare Entity - Report of Two Cases in HIV-Uninfected Patients from a Single Institution"],"prefix":"10.1159","volume":"59","author":[{"given":"Marta","family":"Nicola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Onorati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Luisa","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bellone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Di Nuovo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2014.48.2.81"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505043321802"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.013"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808133390705"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-5-569"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000363223"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23597"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2014.01010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2014.6"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/441938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:05:13Z","timestamp":1745431513000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000441938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000441938","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}