{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:35:20Z","timestamp":1791725720118,"version":"4.3.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Purpose:<\/i><\/b> We investigated the electrical impedance and expression of tight junction components of the turbinate mucosa, nasal polyp, and normal skin. <b><i>Procedures:<\/i><\/b> The inferior turbinate and nasal polyp of patients with chronic rhinosinusitis and the postauricular skin of patients with otitis media were examined. Electrical impedance was measured in vivo using a tissue conductance meter. Expressions of claudin-1 and tricellulin were examined by fluorescence immunohistochemistry and quantitative RT-PCR. <b><i>Results:<\/i><\/b> Electrical impedance was higher in the skin than in the turbinate and polyp, but did not differ between the turbinate and polyp. Immunoreactivities for claudin-1 and tricellulin were seen in the epithelial\/epidermal layer. Expression of <i>claudin-1<\/i> was higher in the skin than in the turbinate and polyp. The polyp tended to show higher expression of <i>claudin-1<\/i> but showed lower expression of <i>tricellulin<\/i> than the turbinate. The ratio of <i>claudin-1<\/i> to <i>tricellulin<\/i> was highest in the skin and lowest in the turbinate. The correlation between expressions of the two tight junction components was strongly positive in the skin (r = 0.964) and negative (r = -0.527) in the turbinate and polyp. <b><i>Conclusions:<\/i><\/b> These results suggest that the roles of claudin-1 and tricellulin in barrier function may be complementary, and may thereby maintain a constant level of permeability of the mucosal tissues.<\/jats:p>","DOI":"10.1159\/000442024","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T22:01:21Z","timestamp":1449180081000},"page":"16-25","source":"Crossref","is-referenced-by-count":10,"title":["Electrical Impedance and Expression of Tight Junction Components of the Nasal Turbinate and Polyp"],"prefix":"10.1159","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-1939","authenticated-orcid":false,"given":"Hideaki","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Ikezaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5175-4089","authenticated-orcid":false,"given":"Takuro","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobusuke","family":"Hohchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000239111.24094.a3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.08.025"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S8088"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.6.588"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2166-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3503"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12332"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6539.2005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-009-0470-y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000362246"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000091973"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12038"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200110122"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2012.12.020"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02478741"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000216742.23127.7A"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.280"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.233049"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.05.018"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.02.037"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2333(97)00015-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00267.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.08.013"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-05-0530"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114306"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:05:46Z","timestamp":1745431546000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,4]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,3,1]]},"published-print":{"date-parts":[[2016,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000442024","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,4]]}}}