{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:33:17Z","timestamp":1745469197733,"version":"3.40.4"},"reference-count":37,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T00:00:00Z","timestamp":1448064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T00:00:00Z","timestamp":1448064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>This study investigated the effect of the metabolic syndrome associated risk factors hyperglycemia (glucose [Glc]), hyperinsulinemia (insulin [Ins]) and low-grade inflammation (tumor necrosis factor \u03b1 [TNF\u03b1]) on the vasomotor responses of resistance arteries. Isolated small mesenteric arteries from 3-month-old Sprague-Dawley rats, were suspended for 21-23 h in tissue cultures containing either elevated Glc (30 mmol\/l), Ins (100 nmol\/l), TNF\u03b1 (100 ng\/ml) or combinations thereof. After incubation, the vascular response to noradrenaline (NA), phenylephrine, isoprenaline and NA in the presence of propranolol (10 \u00b5mol\/l) was measured by wire myography. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Arteries exposed only to combinations of the risk factors showed a significant 1.6-fold increase in the contractile NA sensitivity, which suggests that complex combinations of metabolic risk factors might lead to changes in vascular tone.<\/jats:p>","DOI":"10.1159\/000442259","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T22:01:24Z","timestamp":1448056884000},"page":"48-56","source":"Crossref","is-referenced-by-count":1,"title":["Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric 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