{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:37:42Z","timestamp":1785832662867,"version":"3.56.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; This study aimed to examine the clinical significance of carbohydrate antigen 125 (CA125) and human epididymis protein 4 (HE4) serum levels in combination for ovarian cancer detection in patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In total, 75 patients with ovarian cancer, 86 patients with benign ovarian tumors, 75 patients with endometriosis and 34 healthy women (as a control group) were selected from January 2012 to July 2015 at Anhui province hospitals. The sensitivity and specificity of detection of CA125, HE4 and combined CA125 + HE4 in serum were analyzed for each group. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; HE4 and CA125 serum levels in the ovarian cancer group were higher than those in the other 3 groups (p &lt; 0.001). The sensitivity of CA125 was higher than that of HE4 (88.2 vs. 54.7%, respectively), whereas the specificity of HE4 was higher than that of CA125 (97.9 vs. 67.4%, respectively). In contrast, the sensitivity and specificity of HE4 combined with CA125 were 82.7 and 91.4%, respectively. The receiver operating characteristic-area under the curve values of HE4, CA125 and HE4 + CA125 were 0.889, 0.893 and 0.925, respectively. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Combined detection of CA125 with HE4 can improve the sensitivity and specificity of ovarian cancer diagnosis and has certain clinical significance that can guide treatment planning.<\/jats:p>","DOI":"10.1159\/000442288","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T21:25:02Z","timestamp":1461878702000},"page":"430-435","source":"Crossref","is-referenced-by-count":31,"title":["CA125 and HE4: Measurement Tools for Ovarian Cancer"],"prefix":"10.1159","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2781-0989","authenticated-orcid":false,"given":"Tingting","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2001.11(suppl.1)sup1003.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/475983"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-1945-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00441.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22594"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2011.011258"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31819cda77"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.157073"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.04.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.10.087"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2011.04.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10261-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0808-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1757-2215-6-44"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-11"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2011.22.4.244"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442288","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:07:44Z","timestamp":1745431664000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,9,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000442288","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}