{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:22:11Z","timestamp":1785295331125,"version":"3.55.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; CT, MRI and ultrasound are currently used for screening and follow-up of individuals affected by autosomal dominant polycystic kidney disease (ADPKD). Dynamic contrast-enhanced MRI studies renal perfusion after gadolinium administration, with possible side effects, such as nephrogenic systemic fibrosis. The aim of our study was to evaluate the clinical application of 3 Tesla (3T)-diffusion tensor image (DTI) in ADPKD patients, correlating its parameters, such as fractional anisotropy (FA), and apparent diffusion coefficient (ADC) with kidney function tests. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Eight ADPKD patients and 6 healthy volunteers (HS) were enrolled. FA and ADC mean values were calculated. And correlations between DTI-parameters, creatinine and estimated glomerular filtration rate (eGFR) were evaluated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Parenchymal FA was significantly lower in ADPKD than HS (FA: 0.17 \u00b1 0.03 vs. 0.22 \u00b1 0.01; p = 0.02), whereas parenchymal ADC was higher in patients than controls (2.48 (\u00d710&lt;sup&gt;-3&lt;\/sup&gt;) \u00b1 0.16 vs. 2.28 (\u00d710&lt;sup&gt;-3&lt;\/sup&gt;) \u00b1 0.09), but a statistically significant difference was not achieved (p = 0.27). Direct correlations were revealed between eGFR and FA (r = 0.82; p = 0.0003), whereas an inverse correlation was found with creatinine (r = -0.77; p = 0.001). Similarly, ADC closely correlated with creatinine (r = 0.79; p = 0.0006) and eGFR (r = -0.620; p = 0.01). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; 3T-DTI is a promising radiological tool that could be used by nephrologists to evaluate ADPKD patients, highlighting early micro-structure alterations, without side effects and contrast agent administration.<\/jats:p>","DOI":"10.1159\/000442296","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T21:01:22Z","timestamp":1470776482000},"page":"73-80","source":"Crossref","is-referenced-by-count":13,"title":["3 Tesla-Diffusion Tensor Imaging in Autosomal Dominant Polycystic Kidney Disease: The Nephrologist's Point of View"],"prefix":"10.1159","volume":"134","author":[{"given":"Rosaria","family":"Lupica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enricomaria","family":"Mormina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lacquaniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Trimboli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"Bianchimano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Placido","family":"Bramanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Buemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Granata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008050507"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.08.007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20401"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.159.3.1503032"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.161.2.3763909"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(200002)11:2<156::AID-JMRI12>3.0.CO;2-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360612"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.781"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31817d14e6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2011.02.032"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2189-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31824f272d"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000333044"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181d83abc"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3461-x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09500911"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000256657"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1473-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4368"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9377-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00987"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.3.7972811"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12277"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010183231602"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120578"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-013-0485-7"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:07:52Z","timestamp":1745431672000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,10,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000442296","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}