{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:48:04Z","timestamp":1780332484287,"version":"3.54.1"},"reference-count":41,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Thyroid disease has been mentioned to have a possible relation to the development of oral lichen planus (OLP). &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Because goiter is considered endemic in many countries, we proposed to determine whether thyroid disease constitutes a comorbidity of OLP. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Two hundred and fifteen patients diagnosed as having OLP were evaluated concerning their serum thyroid-stimulating hormone and thyroxine (T&lt;sub&gt;4&lt;\/sub&gt;) levels. The results were contrasted with those obtained in control series of the same number of subjects matched for age and sex. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Diagnosis of thyroid disease was present in 15.3% of OLP patients (33\/215) and in 5.2% (12\/215) of the control group. In relation to OLP patients, the odds ratio of presence of thyroid disorders was 3.06 and that of using levothyroxine medication 3.21. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; In the present study, OLP patients were associated with thyroid disease, specifically with hypothyroidism. Because most thyroid patients need T&lt;sub&gt;4&lt;\/sub&gt; treatment, our findings confirmed that OLP and thyroid disease could be comorbidities.<\/jats:p>","DOI":"10.1159\/000442438","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T22:44:12Z","timestamp":1453243452000},"page":"214-219","source":"Crossref","is-referenced-by-count":41,"title":["Thyroid Disease and Oral Lichen Planus as Comorbidity: A Prospective Case-Control Study"],"prefix":"10.1159","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-9944","authenticated-orcid":false,"given":"Maria Jos\u00e9","family":"Garcia-Pola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Llorente-Pend\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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