{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:42:18Z","timestamp":1782931338220,"version":"3.54.5"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Background:<\/i><\/b> Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. <b><i>Aims:<\/i><\/b> To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. <b><i>Methods:<\/i><\/b> A prospective study was performed in 43 CPP girls. Serum luteinizing hormone and follicle-stimulating hormone at 3 h (LH-3h, FSH-3h) and estradiol at 24 h (E<sub>2<\/sub>-24h) after injection of depot triptorelin 3.75 mg were measured, at first dose and at 3, 6, 12, 18 and 24 months of treatment. <b><i>Results:<\/i><\/b> E<sub>2<\/sub>-24h after depot triptorelin was >100 pg\/ml after the first dose. Estradiol response (E<sub>2<\/sub>-24h) fell to levels <14 pg\/ml in 78 out of 82 follow-up visits along 2 years of therapy. Concomitantly, LH-3h and FSH-3h were <4.0 and <6.3 IU\/l, respectively. In 4 patients with inadequate treatment, E<sub>2<\/sub>-24h, LH-3h and FSH-3h rose to pubertal values similar to those observed at first dose. <b><i>Conclusion:<\/i><\/b> Estradiol (<14 pg\/ml) assessment 24 h after depot triptorelin administration is a reliable and simple manner to confirm ovarian suppression in CPP girls during treatment.<\/jats:p>","DOI":"10.1159\/000442523","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T22:15:04Z","timestamp":1450304104000},"page":"58-64","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty"],"prefix":"10.1159","volume":"85","author":[{"given":"Anal\u00eda Ver\u00f3nica","family":"Freire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirta Graciela","family":"Gryngarten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Gabriela","family":"Ballerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Josefina","family":"Arcari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Bergad\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Gabriela","family":"Ropelato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800459"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000366282"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1783"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.12.6181"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1994.02170040035006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000023275"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2007.20.11.1189"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2000.13.S1.723"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04517.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.5.1547"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh519"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.e30"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031537"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04185.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80767-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.08.038"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2013-20"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:09:37Z","timestamp":1745431777000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000442523","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,17]]}}}