{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:50:53Z","timestamp":1763747453931,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Diuretics are administered to neonates to control fluid balance. We studied whether clinical doses affected kidney development and function and whether extrauterine growth retardation (EUGR) could be a modulator. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Wistar rats were cross-fostered in normal food or food restricted litters at postnatal day (PND) 2 and treated daily with 0.9% NaCl, 5 mg\/kg furosemide or 5 mg\/kg hydrochlorothiazide (HCTZ) up to PND 8. Kidneys were evaluated on proliferation, apoptosis and a set of mRNA target genes at PND 8, glomerular- and glomerular generation count at PND 35, clinical pathology parameters at 3- and 9 months, neutrophil gelatinase-associated lipocalin at PND 8, 3 and 6 months, monthly blood pressure from 3 months onward and histopathology at study end. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Treatment with furosemide or HCTZ did not have relevant effects on measured parameters. EUGR resulted in lower body weight from day 3 onwards (-29% at weaning; p &lt; 0.001, -10% at necropsy; p &lt; 0.001), less glomerular generations (4.4 \u00b1 0.32 vs. 5.0 \u00b1 0.423; p = 0.025, males only), decreased glomerular numbers (27,861 \u00b1 3,468 vs. 30,527 \u00b1 4,096; p = 0.026), higher creatinine clearance (0.84 \u00b1 0.1 vs. 0.77 \u00b1 0.09 ml\/min\/kg; p = 0.047) at 3 months and lower plasma creatinine (25.7 \u00b1 1.8 vs. 27.5 \u00b1 2.8 \u00b5mol\/l; p = 0.043) at 9 months. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Furosemide and HCTZ did not influence kidney development or function when administered in a clinically relevant dose to rat pups at a stage of ongoing nephrogenesis. EUGR led to impaired kidney development but did not modify furosemide or HCTZ findings.<\/jats:p>","DOI":"10.1159\/000442674","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T22:01:27Z","timestamp":1453759287000},"page":"110-118","source":"Crossref","is-referenced-by-count":4,"title":["The Effects of Early Postnatal Diuretics Treatment on Kidney Development and Long-Term Kidney Function in Wistar Rats"],"prefix":"10.1159","volume":"132","author":[{"given":"Ruud R.G.","family":"Bueters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Jeronimus-Klaasen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Maicas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Florquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambertus P.","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel F.","family":"Schreuder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12176"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00018.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.10.1472"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2169-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1843-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.08.021"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001817.pub2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2009.02886.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050139"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.21090"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00128.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00158.2006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000020541"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2003.10.023"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200104000-00005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S0958067000019394"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00119.2007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2013.03.001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.265"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.7.761"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13726.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000190576.08501.df"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000079868"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000158419.98675.d7"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.4.920"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442674","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:11:05Z","timestamp":1745431865000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000442674","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4236470","asserted-by":"subject"}]},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"type":"print","value":"1660-8151"},{"type":"electronic","value":"2235-3186"}],"subject":[],"published":{"date-parts":[[2016]]}}}