{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:42:32Z","timestamp":1762875752530,"version":"3.40.5"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aims:&lt;\/i&gt;&lt;\/b&gt; To report false-negative normal growth hormone (GH) peak response in patients with ectopic posterior pituitary gland (EPP) identified with a simplified magnetic resonance imaging (FAST1-MRI). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We analyzed 75 EPP patients with short stature and reduced growth velocity. Sagittal-T1 imaging (thickness: 2 mm and gap: 0.2 mm) without gadolinium administration was used. A GH peak of \u22655 ng\/ml after clonidine or insulin stimulation was considered normal. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Normal GH response was observed in 15 of 75 (20%) patients [mean (SDS) peak = 8.2 (4.1) ng\/ml]. Age at diagnosis [6.5 (3.0) years vs. 7.8 (4.1) years], gender (10 males\/5 females vs. 44 males\/16 females), pubertal stage (14 prepubertal\/1 pubertal vs. 51 prepubertal\/7 pubertal), and target height [-0.4 (0.6) vs. -0.4 (0.9)] were recorded. The perinatal history did not differ between responsive and nonresponsive patients. There was a trend to more frequent multiple hormone deficiency in nonresponsive when compared with responsive patients [3\/15 (20%) and 31\/60 (51.7%), respectively (p = 0.055)]. Height at diagnosis was lower in nonresponsive patients (p = 0.042). No significant difference in the IGF1 levels (p = 0.598) was observed between the groups. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Normal GH values after stimulation tests do not exclude EPP-associated GH deficiency. A simplified fast acquisition sagittal-T1 MRI protocol investigation included at the initial diagnostic approach is able to prevent misdiagnosis of GH deficiency in patients with short stature.<\/jats:p>","DOI":"10.1159\/000442830","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T22:01:57Z","timestamp":1451944917000},"page":"119-124","source":"Crossref","is-referenced-by-count":9,"title":["High Frequency of Normal Response during GH Stimulation Tests in Patients with Ectopic Posterior Pituitary Gland: A Source of False-Negative Diagnosis of Pituitary Insufficiency"],"prefix":"10.1159","volume":"85","author":[{"given":"Cristiane","family":"Kochi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy Greicy Bruginski","family":"Scuderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Amadei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Damaso","family":"Maruichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Jos\u00e9","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-5235","authenticated-orcid":false,"given":"Carlos Alberto","family":"Longui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.7.2408"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000060860"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03236.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.3.222"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2001.14.5.517"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2000.13.9.1577"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2004.17.8.1111"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000101522"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000101809"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2001-011936"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2223\/1187"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-010-0211-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345298"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1996.tb02055.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0321-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.6.1663"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442830","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:36Z","timestamp":1745431956000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000442830","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2016]]}}}