{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:15:11Z","timestamp":1777338911888,"version":"3.51.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The development of synthetic surfactants for the treatment of lung pulmonary diseases has been going on for many years. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To investigate the effects of phospholipid mixtures combined with SP-B and SP-C analogues on lung functions in an animal model of respiratory distress syndrome. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Natural and synthetic phospholipid mixtures with\/without SP-B and\/or SP-C analogues were instilled in ventilated premature newborn rabbits. Lung functions were evaluated. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Treatment with Curosurf\u00ae or phospholipids from Curosurf combined with SP-B and SP-C analogues gave similar results. Treatment with phospholipids from adult rabbit lungs or liver combined with dipalmitoylphosphatidylcholine (DPPC) and palmitoyloleoylphosphatidylglycerol (POPG) gave tidal volumes (V&lt;sub&gt;T&lt;\/sub&gt;) well above physiological levels, but alveolar stability at end-expiration was only achieved when these phospholipids were combined with analogues of SP-B and SP-C. Treatment with egg yolk-PC mixed with DPPC with and without POPG gave small V&lt;sub&gt;T&lt;\/sub&gt;, but after addition of both analogues V&lt;sub&gt;T&lt;\/sub&gt; was only somewhat lower and lung gas volumes (LGV) similar to those obtained with Curosurf. Substitution of egg yolk-PC (\u226599% PC) with 1-palmitoyl-2-oleoyl-&lt;i&gt;sn&lt;\/i&gt;-glycero-3-phosphocholine and 1-palmitoyl-2-linoleoyl-&lt;i&gt;sn&lt;\/i&gt;-glycero-3-phosphocholine, and combining them with DPPC, POPG and 2% each of the SP-B and SP-C analogue gave a completely synthetic surfactant with similar effects on V&lt;sub&gt;T&lt;\/sub&gt; and LGV as Curosurf. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Phospholipid composition is important for V&lt;sub&gt;T&lt;\/sub&gt; while the SP-B and SP-C analogues increase alveolar stability at end-expiration. Synthetic surfactant consisting of unsaturated and saturated phosphatidylcholines, POPG and the analogues of SP-B and SP-C has similar activity as Curosurf regarding V&lt;sub&gt;T&lt;\/sub&gt; and LGV in an animal model using preterm newborn rabbits ventilated without positive end-expiratory pressure.<\/jats:p>","DOI":"10.1159\/000442874","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T01:04:07Z","timestamp":1452647047000},"page":"177-185","source":"Crossref","is-referenced-by-count":17,"title":["Phospholipid Composition in Synthetic Surfactants Is Important for Tidal Volumes and Alveolar Stability in Surfactant-Treated Preterm Newborn Rabbits"],"prefix":"10.1159","volume":"109","author":[{"given":"Andrea","family":"Calkovska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bim","family":"Linderholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Haegerstrand-Bj\u00f6rkman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pioselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Pelizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore","family":"Curstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000297767"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000349942"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.2.97-08019"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00153.2003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00865.2007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000276980"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039392"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047631"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000381117"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000360649"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(93)90181-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10552.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819fb42c"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.80"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(98)00107-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(81)90211-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(01)00312-9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00060-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.04.035"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-73305-5_39"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9908104"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.5.8173774"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2008.07.007"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00496.2004"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442874","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/442874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:12:42Z","timestamp":1745431962000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000442874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000442874","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}