{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:52Z","timestamp":1787017912929,"version":"build-2736575974"},"reference-count":30,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Currently, there is an inadequate number of studies on nodule and malignancy development in children and adolescents with Hashimoto thyroiditis (HT). &lt;b&gt;&lt;i&gt;Material and Methods:&lt;\/i&gt;&lt;\/b&gt; Patients who were diagnosed with HT between 2004 and 2013 were included in the study. The HT diagnosis was made with a heterogeneous appearance on thyroid ultrasonography and the elevation of antithyroid peroxidase and\/or anti-thyroglobulin antibodies. Fine-needle aspiration biopsy (FNAB) was performed in cases with a nodule size &gt;1 cm or who had ultrasonography findings indicating malignancy. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 39 (13%) thyroid nodules were detected in 300 patients with a diagnosis of HT. Papillary thyroid carcinoma (PTC) was diagnosed in 2 of the 12 cases in whom FNAB was performed. The thyroid nodule was detected at the same time as HT in the 2 cases with malignancy. The PTC diagnosis was made 2 years after the HT diagnosis in the first case and 3 years later in the second case. The largest diameter of the thyroid nodule was 5 mm in both cases. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The thyroid nodule rate on an HT background was found to be 13%, and the thyroid malignancy rate was 0.67% in our study.<\/jats:p>","DOI":"10.1159\/000443143","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T20:24:43Z","timestamp":1456345483000},"page":"181-187","source":"Crossref","is-referenced-by-count":27,"title":["Co-Existence of Thyroid Nodule and Thyroid Cancer in Children and Adolescents with Hashimoto Thyroiditis: A Single-Center Study"],"prefix":"10.1159","volume":"85","author":[{"given":"Meliksah","family":"Keskin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senay","family":"Savas-Erdeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00882"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1796"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4274\/Jcrpe.853"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.06.026"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0373"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000363162"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1955.01270080137023"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951201)76:11<2312::AID-CNCR2820761120>3.0.CO;2-H"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.09.020"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21518"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02892.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0450"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0273"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2014-0268"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.6.526"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2010.114"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/156482650802900305"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-610"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0527"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0373-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0036"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.08.028"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12027"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/02841860050215963"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.003"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.5935\/1808-8694.20120037"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)80004-X"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200111000-00005"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1177\/106689690000800305"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:34:40Z","timestamp":1745415280000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000443143","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}