{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:12:56Z","timestamp":1775095976493,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Background and Objective:<\/i><\/b> Severe neonatal anaemia can impair cerebral oxygen supply. Data on long-term outcomes following severe neonatal anaemia are scarce. <b><i>Methods:<\/i><\/b> Clinical data and neurodevelopmental outcome of 49 (near) term infants with haemoglobin concentration after birth <6.0 mmol\/l were retrospectively collected and analysed. In a subgroup of 28 patients, amplitude-integrated EEG was available and in 25 infants cerebral MRI was obtained. Infants were followed up at 14-35 months of age and assessed with the Griffiths Scale of Mental Development or Bayley Scale of Infant Development. <b><i>Results:<\/i><\/b> Eighteen patients (37%) died during the neonatal period. In 25 patients MRI was performed. A predominant pattern of injury on MRI was seen in the basal ganglia and thalami in 7 patients (28%), whereas some form of white matter injury was present in 16 (64%) and a combination in 3 (12%). Follow-up data were available for 26 patients (84% of survivors). Formal assessment of neurodevelopmental outcome was performed in 20 of 31 (65%) infants who survived (median age: 19 months, range: 14-35). Sixteen infants (80%) had a developmental quotient appropriate for age in the first 2 years after birth. On motor outcome, 1 patient (5%) scored below average (Z-score -1.10). One patient developed cerebral palsy. <b><i>Conclusion:<\/i><\/b> Early neurodevelopmental outcome in surviving patients with severe neonatal anaemia was within the normal range in the majority of the survivors. MRI showed mild-to-moderate white matter injury in two thirds of the infants. Prospectively collected data with a longer follow-up period are needed.<\/jats:p>","DOI":"10.1159\/000443320","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T22:02:21Z","timestamp":1455746541000},"page":"282-288","source":"Crossref","is-referenced-by-count":15,"title":["Severe Neonatal Anaemia, MRI Findings and Neurodevelopmental Outcome"],"prefix":"10.1159","volume":"109","author":[{"given":"Inge A.","family":"Zonnenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Jeroen","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maartje W.","family":"Rohaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam M.","family":"van Weissenbruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-1637","authenticated-orcid":false,"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702848"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0770"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2822"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.04.054"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110213"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087874"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821f442d"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.04.054"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.06.033"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70295-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2492071581"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12122"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.02.003"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443320","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:36:43Z","timestamp":1745429803000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,6,3]]},"published-print":{"date-parts":[[2016,6,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000443320","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}