{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:34:07Z","timestamp":1782264847400,"version":"3.54.5"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>The total bilirubin value of a male infant was 385 \u03bcmol\/l on day 5. Liver function test results were normal and there was no evidence of sepsis and no hemolysis reaction. Phototherapy was administered and on day 8 the patient's total bilirubin level was 255 \u03bcmol\/l. Intermittent episodes of hyperbilirubinemia occurred without phototherapy, with the total bilirubin level reaching 335 \u03bcmol\/l on day 19. A 3-day regimen of phenobarbital was administered and on day 24 his total bilirubin level was 180 \u03bcmol\/l. The patient was discharged. At the age of 2 months, the total bilirubin value was 27 \u03bcmol\/l. His direct bilirubin value was &lt;15% of total bilirubin in every determination. A family study of the &lt;i&gt;UDP-glucuronosyltransferase&lt;\/i&gt;&lt;i&gt;(UGT)&lt;\/i&gt;&lt;i&gt;1A1 &lt;\/i&gt;gene showed that the infant carries a homozygous mutation at nucleotide -3279 plus compound heterozygous mutations at nucleotides 782 and 1091. The mutation at nucleotide 782 is a novel finding. Gilbert's syndrome was diagnosed.<\/jats:p>","DOI":"10.1159\/000443365","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T22:02:49Z","timestamp":1455055369000},"page":"235-238","source":"Crossref","is-referenced-by-count":5,"title":["Prolonged Hyperbilirubinemia in a Neonate with a Novel Mutation in the &lt;b&gt;&lt;i&gt;UDP-glucuronosyltransferase 1A1&lt;\/i&gt;&lt;\/b&gt; Gene"],"prefix":"10.1159","volume":"109","author":[{"given":"Shu-Chi","family":"Mu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yi","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Luen","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Sung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-12-RV-096"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.9.1229"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200008000-00007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000141846.37253.AF"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6683"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03370.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.03.047"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2013.01.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.027409"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2011.00754.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1003-9406.2013.04.010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.68"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000354884"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000363219"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000365586"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443365","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:37:03Z","timestamp":1745429823000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000443365","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}