{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:40:09Z","timestamp":1790178009688,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Background: Radiosurgery is one of the neurosurgical alternatives for intractable trigeminal neuralgia (TN). Objective: Although acceptable short-\/mid-term outcomes have been reported, long-term results have not been well documented. Methods: We report the long-term results in 130 patients who underwent radiosurgery for classical TN and were subsequently monitored through at least 7 years (median = 9.9, range = 7-14.5) of follow-up. Results: The median age was 66.5 years. A total of 122 patients (93.8%) became pain free (median delay = 15 days) after the radiosurgery procedure (Barrow Neurological Institute, BNI class I-IIIa). The probability of remaining pain free without medication at 3, 5, 7 and 10 years was 77.9, 73.8, 68 and 51.5%, respectively. Fifty-six patients (45.9%) who were initially pain free experienced recurrent pain (median delay = 73.1 months). However, at 10 years, of the initial 130 patients, 67.7% were free of any recurrence requiring new surgery (BNI class I-IIIa). The new hypesthesia rate was 20.8% (median delay of onset = 12 months), and only 1 patient (0.8%) reported very bothersome hypesthesia. Conclusions: The long-term results were comparable to those from our general series (recently published), and the high probability of long-lasting pain relief and rarity of consequential complications of radiosurgery may suggest it as a first- and\/or second-line treatment for classical, drug-resistant TN.<\/jats:p>","DOI":"10.1159\/000443529","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T17:01:29Z","timestamp":1455642089000},"page":"24-32","source":"Crossref","is-referenced-by-count":63,"title":["The Very Long-Term Outcome of Radiosurgery for Classical Trigeminal Neuralgia"],"prefix":"10.1159","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-3753","authenticated-orcid":false,"given":"Jean","family":"R\u00e9gis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Tuleasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Resseguier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Carron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Donnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Yomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gaudart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Levivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-012-0023-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604253341701"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000168"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3171\/2009.7.JNS09694"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.6.913"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02185.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3171\/2009.2.JNS08977"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3171\/2015.2.JNS142144"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3171\/2013.1.JNS12875"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000362173"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2003.00824.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2005.18.5.4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01606-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01405533"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000068862.78930.EE"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00513-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.6.0940"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.12.2347"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000739"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199304000-00012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.72.6.0851"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000739"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/sfn\/article-pdf\/94\/1\/24\/3906107\/000443529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/sfn\/article-pdf\/94\/1\/24\/3906107\/000443529.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:39:07Z","timestamp":1745415547000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,4,1]]},"published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000443529","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}