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Karger AG","issue":"6","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Important steps during the prenatal development of the bovine uterus are described using conventional hematoxylin-eosin staining of fetuses from different developmental stages [crown-rump length (CRL) 9.2-94.0 cm]. Additionally, a number of intermediate filaments (keratin 7, 8, 14, 18, 19; and vimentin), the basement membrane protein laminin, smooth-muscle marker (SMA), and S100 were studied to further characterize certain differentiation processes. During early development, the uterine epithelium is simple or (pseudo)stratified with bud-like protrusions. Developing caruncles can be observed in the corpus uteri at a CRL of 15.8 cm onwards, showing a simple, keratin-positive epithelium. In contrast, the intercaruncular areas are characterized by a (pseudo)stratified epithelium, which also shows positive staining in a different manner for the investigated keratins. A differentiation of smooth muscle cell layers can be observed from a CRL of 24.4 cm onwards. Intense SMA-positive cells\/fibers, arranged perpendicularly to the developing circular SMA-positive muscle cell layer, can be found preferentially located in the developing caruncles. Lymphocytes occur in the uterine epithelium and stroma in the corpora and cornua of fetuses with a CLR of 15.8 cm and higher.<\/jats:p>","DOI":"10.1159\/000443600","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T02:20:48Z","timestamp":1457144448000},"page":"316-326","source":"Crossref","is-referenced-by-count":1,"title":["Fetal Development of the Bovine Uterus: A Light Microscopy and Immunohistochemical Study"],"prefix":"10.1159","volume":"9","author":[{"given":"Rebecca A.-M.","family":"Kenngott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Sinowatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.64.3.692"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod30.3.763"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000016799"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.015990"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1982.tb01266.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.5.1311"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1250185"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00342"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2006.00762.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2007.00835.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000348881"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0550173"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199810)213:2<228::AID-AJA8>3.3.CO;2-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(86)90356-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1985.tb00290.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.09.035"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod63.4.1192"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1987.tb00065.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2508\/chikusan.35.tokubetu_92"}],"container-title":["Sexual Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443600","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:39:21Z","timestamp":1745429961000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,3,1]]},"published-print":{"date-parts":[[2016,3,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000443600","archive":["Portico"],"relation":{},"ISSN":["1661-5425","1661-5433"],"issn-type":[{"type":"print","value":"1661-5425"},{"type":"electronic","value":"1661-5433"}],"subject":[],"published":{"date-parts":[[2015]]}}}