{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:31:25Z","timestamp":1745469085030,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Objective:<\/i><\/b> To explore the associations of matrix metalloprotease-2 (<i>MMP-2<\/i>), <i>MMP-7<\/i> and <i>MMP-9<\/i> methylations and messenger ribonucleic acid (mRNA) expressions with primary fallopian tube carcinoma (PFTC) development and prognosis. <b><i>Methods:<\/i><\/b> We recruited 48 patients with PFTC into the case group and 48 healthy individuals into the control group; PFTC tissues and normal fallopian tube tissues were obtained from subjects in both groups. Methylation specific polymerase chain reaction (PCR), reverse transcription PCR and the immunohistochemical method were used to examine methylation, mRNA expressions and protein expressions of <i>MMP-2<\/i>, <i>MMP-7<\/i> and <i>MMP-9<\/i>, respectively. <b><i>Results:<\/i><\/b> The methylation rates of <i>MMP-2<\/i>, <i>MMP-7 <\/i>and <i>MMP-9<\/i> in the case group were significantly lower than those in the control group (all p < 0.05); MMP-2, MMP-7 and MMP-9 protein and mRNA expressions of PFTC tissues were enormously higher than those of normal tissues (all p < 0.05); univariate survival analysis indicated that <i>MMP-2<\/i> and <i>MMP-9<\/i> methylations and their protein expressions were associated with PFTC prognosis (all p < 0.05), which was further confirmed by the Cox regression model (all p < 0.05). <b><i>Conclusion:<\/i><\/b> The protein and mRNA expressions of MMP-2, MMP-7 and MMP-9 might be related to PFTC, while the methylations and protein expressions of <i>MMP-2<\/i> and <i>MMP-9 <\/i>might be associated with PFTC progression and prognosis.<\/jats:p>","DOI":"10.1159\/000443639","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T22:44:12Z","timestamp":1453243452000},"page":"367-374","source":"Crossref","is-referenced-by-count":2,"title":["Associations of Promoter Methylations and mRNA Expressions of <b><i>MMP-2<\/i><\/b>, <b><i>MMP-7<\/i><\/b> and <b><i>MMP-9<\/i><\/b> with Primary Fallopian Tube Carcinoma"],"prefix":"10.1159","volume":"81","author":[{"given":"Yuefang","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinjian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingsong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2014.07.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.12.007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2011.01.031"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/630731"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203543"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3125"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.2000.0379"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123979"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.3041"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2589-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1586\/erm.09.53"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.07.014"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4340"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387685-0.00009-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/nu7075065"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2726-y"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2383-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.01869.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01485.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nm846"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3721"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3177"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3203"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01052.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1052"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123781"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443639","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:39:44Z","timestamp":1745429984000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,7,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000443639","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2016]]}}}