{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:45:11Z","timestamp":1792518311870,"version":"4.5.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<b><i>Background:<\/i><\/b> Phenobarbitone is the most common first-line anti-seizure drug and is effective in approximately 50% of all neonatal seizures. <b><i>Objective:<\/i><\/b> To describe the response of electrographic seizures to the administration of intravenous phenobarbitone in neonates using seizure burden analysis techniques. <b><i>Methods:<\/i><\/b> Multi-channel conventional EEG, reviewed by experts, was used to determine the electrographic seizure burden in hourly epochs. The maximum seizure burden evaluated 1 h before each phenobarbitone dose (T<sub>-1<\/sub>) was compared to seizure burden in periods of increasing duration after each phenobarbitone dose had been administered (T<sub>+1<\/sub>, T<sub>+2<\/sub> to seizure offset). Differences were analysed using linear mixed models and summarized as means and 95% CI. <b><i>Results:<\/i><\/b> Nineteen neonates had electrographic seizures and met the inclusion criteria for the study. Thirty-one doses were studied. The maximum seizure burden was significantly reduced 1 h after the administration of phenobarbitone (T<sub>+1<\/sub>) [-14.0 min\/h (95% CI: -19.6, -8.5); p < 0.001]. The percentage reduction was 74% (IQR: 36-100). This reduction was temporary and not significant within 4 h of administrating phenobarbitone. Subgroup analysis showed that only phenobarbitone doses at 20 mg\/kg resulted in a significant reduction in the maximum seizure burden from T<sub>-1<\/sub> to T<sub>+1<\/sub> (p = 0.002). <b><i>Conclusions:<\/i><\/b> Phenobarbitone significantly reduced seizures within 1 h of administration as assessed with continuous multi-channel EEG monitoring in neonates. The reduction was not permanent and seizures were likely to return within 4 h of treatment.<\/jats:p>","DOI":"10.1159\/000443782","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:48:48Z","timestamp":1459381728000},"page":"40-46","source":"Crossref","is-referenced-by-count":19,"title":["Short-Term Effects of Phenobarbitone on Electrographic Seizures in Neonates"],"prefix":"10.1159","volume":"110","author":[{"given":"Evonne","family":"Low","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R.","family":"Mathieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Livingstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Rennie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0920-5291","authenticated-orcid":false,"given":"Geraldine B.","family":"Boylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.10.026"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.86.3.F165"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410704"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2013.04.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3233\/JPN-2009-0270"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02132.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.086314"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-012-0004-y"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/fn.89.1.F37"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31825bbbc2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2006.06.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(95)00245-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1769-10.2010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328010c536"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1987.tb05753.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(02)00085-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr041"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03401.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01809.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2013.04.004"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:41:07Z","timestamp":1745430067000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,6,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000443782","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4028895","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}