{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:07:16Z","timestamp":1790719636478,"version":"4.1.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; There is no data available whether sedation should be given during minimally invasive surfactant therapy (MIST). &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To compare the level of comfort of preterm infants receiving sedation versus no sedation for MIST. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A retrospective study of preterm infants receiving MIST was performed in Leiden University Medical Center in 2014. Sedation (propofol 1 mg\/kg) was optional and left to the discretion of the caregiver. Standardized COMFORTneo scores were compared, and COMFORTneo &lt;14 was considered comfortable. Basic characteristics and complications were noted. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In 38 infants receiving MIST, 23 received propofol and 15 were not sedated. Mean (SD) gestational age [29 (2) vs. 29 (3) weeks] and birth weight [1,312 (483) vs. 1,469 (588) g] were not different. Median (IQR) COMFORTneo was not different between the groups before [11 (9-15) vs. 10 (8-12)] and after MIST [10 (8-12) vs. 9 (8-10)], but lower in the sedated group during MIST [12 (9-17) vs. 20 (15-23)] with more often COMFORTneo &lt;14 (56 vs. 11%). Duration of MIST [2 (2-4) vs. 3 (2-7) min] and occurrence of bradycardia (13 vs. 33%) and hypotension (21 vs. 18%) were not different. Although not significant, intubation occurred more often in the sedated group (during MIST: 9 vs. 0%, &lt;24 h after MIST: 26 vs. 13%). During MIST, oxygen saturation &lt;80% lasted longer in the sedated group [3 (2-4) vs. 1 (0-2) min], and nasal intermittent positive pressure ventilation was applied more (100 vs. 33%). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Preterm infants receiving MIST were more comfortable when sedation was given, but needed ventilation more often. A randomized controlled trial is warranted to test whether the benefit of sedation outweighs the risks of complications.<\/jats:p>","DOI":"10.1159\/000443823","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T22:01:35Z","timestamp":1456264895000},"page":"308-313","source":"Crossref","is-referenced-by-count":58,"title":["Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants"],"prefix":"10.1159","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-3587","authenticated-orcid":false,"given":"Janneke","family":"Dekker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Rijken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rijntjes-Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianne","family":"Smits-Wintjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"te Pas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3848"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072788"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301314"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00251.2009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1241867"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12611"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.192518"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60986-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198709000-00012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13040.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80558-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/60.2.167"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80137-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00132586-198502000-00049"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009904"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2708"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03330.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnn.2006.11.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1148"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2008.00043.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000271224"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12367"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03552.x"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443823","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:41:37Z","timestamp":1745430097000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,6,3]]},"published-print":{"date-parts":[[2016,6,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000443823","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.4029000","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}