{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:27:20Z","timestamp":1774535240663,"version":"3.50.1"},"reference-count":35,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The vitamin D endocrine system, besides multiple other functions, regulates aging in many tissues, including the skin. It protects the skin against the hazardous effects of many skin age-inducing agents, including ultraviolet radiation. Thus, in the present study we aimed to investigate the relationship between facial skin aging and 25-hydroxyvitamin D [25(OH)D] serum levels in healthy Egyptian adults. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Sixty-one healthy adult subjects were included. Photodamage scores (erythema\/telangiectasias, lentigines, hyperpigmentation and coarse wrinkling) were assessed and graded. Serum&lt;b&gt; &lt;\/b&gt;vitamin D was measured using enzyme immunoassay and subjects were classified as sufficient, insufficient or deficient according to the vitamin level. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The mean 25(OH)D serum level was 43.90 nmol\/l. A high prevalence of vitamin D deficiency was detected in the studied subjects regardless of their age or gender. Also, vitamin D levels were not correlated with photodamage scores and were not affected by the Fitzpatrick skin phototype, duration of sun exposure per day or the use of sunscreens (p &gt; 0.05 for all). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Aging is a complex process that is influenced by many genetic and environmental factors. Facial aging is not correlated with serum vitamin D level, and clinical trials using oral or topical vitamin D to combat aging are better predictors of its effects rather than in vivo studies.<\/jats:p>","DOI":"10.1159\/000443839","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T21:02:21Z","timestamp":1459544541000},"page":"76-82","source":"Crossref","is-referenced-by-count":4,"title":["Serum Vitamin D and Facial Aging: Is There a Link?"],"prefix":"10.1159","volume":"29","author":[{"given":"Noha M.","family":"Dawoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola A.","family":"Bakry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Shoeib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda N.","family":"Ismael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2008.09.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08108.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0567"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4161\/derm.21312"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0376892907003670"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2008.12.020"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2007.00415.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.05.010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.06.006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.09.022"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2007.059113"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-008-0129-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000094932"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2009.01.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.8.863"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2003.01127.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.01.040"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.25"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.02.002"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.14341\/2071-8713-4886"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2004.05.006"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3329\/jhpn.v29i2.7857"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0626-y"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26182"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006477"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2009.03.007"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2004.00116.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2006.11.016"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9646-y"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2005.12.003"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj101"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:41:50Z","timestamp":1745430110000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,5,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000443839","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}