{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:04:24Z","timestamp":1791407064601,"version":"4.3.3"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Accumulating evidence suggests that cannabidiol (CBD) may be an effective and safe anxiolytic agent and potentially also an antidepressant. &lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; The objective of this study was to further examine these properties of CBD using the \u2018depressive-like' Wistar-Kyoto (WKY) rat, focusing on the drug's effect on anhedonia-like behaviors. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Forty-eight WKY and 48 control Wistar adult male rats were pretreated orally with CBD (15, 30 and 45 mg\/kg) or vehicle. The saccharin preference test (SPT), the elevated plus maze (EPM) test and the novel object exploration (NOE) test were used. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; CBD showed a prohedonic effect on the WKY rats at 30 mg\/kg in the SPT. In the NOE, CBD increased exploration of the novel object and locomotion at 45 mg\/kg and increased locomotion at 15 mg\/kg, indicating an improvement in the characteristically low motivation of WKY rats to explore. There was no similar effect at any dose in the EPM or in open-field behavior in the habituation to the NOE. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; These findings extend the limited knowledge on the antidepressant effect of CBD, now shown for the first time in a genetic animal model of depression. These results suggest that CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia.<\/jats:p>","DOI":"10.1159\/000443890","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T22:01:24Z","timestamp":1458856884000},"page":"123-129","source":"Crossref","is-referenced-by-count":99,"title":["Prohedonic Effect of Cannabidiol in a Rat Model of Depression"],"prefix":"10.1159","volume":"73","author":[{"given":"Gal","family":"Shoval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Shbiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liron","family":"Hershkovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Hazut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Zalsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Mechoulam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2016,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.02.040"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.05.016"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2008.00046.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712001502"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2566-z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1048"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.08.006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00521.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2010.03.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.03.003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-458-2_7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200002280-00038"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0810as55"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.03.036"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.05.036"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036743"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.05.008"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.05.039"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12603"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1021\/ja00730a036"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(85)90031-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20012"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20087"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.10.028"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2415-0"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.15"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:42:14Z","timestamp":1745430134000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000443890","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}