{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:29:47Z","timestamp":1747193387988,"version":"3.40.5"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background and Aims:&lt;\/i&gt;&lt;\/b&gt; A sustained virological response (SVR) decreases the incidence of hepatocellular carcinoma (HCC) in patients with hepatitis C. We investigated the long-term outcomes of patients who developed HCC after achieving SVR with interferon therapy. &lt;b&gt;&lt;i&gt;Patients:&lt;\/i&gt;&lt;\/b&gt; Of 75 patients who developed HCC after SVR, 40 patients underwent radical therapies (SVR group). From 436 patients undergoing surgical resection for hepatitis C virus-positive HCC, 80 patients were randomly chosen as a control cohort, after adjusting for age, gender, and extent of hepatic fibrosis (non-SVR group). Patients were observed for a median of 5.08 years. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; HCC recurrence was found in 16 SVR patients and in 66 non-SVR patients. The respective HCC recurrence rates of SVR and non-SVR patients were 23 and 56% at 3 years, 42 and 77% at 5 years, and 53 and 90% at 10 years (p = 0.001). The respective overall survival rates in the SVR and non-SVR groups were 93 and 68% at 5 years, 88 and 34% at 10 years, and 53 and 21% at 15 years (p&lt;i&gt; = &lt;\/i&gt;0.001). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Although SVR patients had a significantly lower HCC recurrence rate than the non-SVR patients, the cumulative recurrence rate of SVR patients increased to 86% at 15 years.<\/jats:p>","DOI":"10.1159\/000443891","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T22:01:34Z","timestamp":1456178494000},"page":"167-175","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Outcomes of Hepatitis-C-Infected Patients Achieving a Sustained Virological Response and Undergoing Radical Treatment for Hepatocellular Carcinoma"],"prefix":"10.1159","volume":"90","author":[{"given":"Hideo","family":"Kunimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushi","family":"Sorin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Fujiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-0042","authenticated-orcid":false,"given":"Yusuke","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Sezaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-2275","authenticated-orcid":false,"given":"Tetsuya","family":"Hosaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-9672","authenticated-orcid":false,"given":"Norio","family":"Akuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitaka","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-5552","authenticated-orcid":false,"given":"Yoshiyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuji","family":"Arase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Kumada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200205303462202"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36806"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10406"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80339-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.594"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26442"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.10.026"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23744"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1519-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.1087"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0384-z"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.1180"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21492"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290439"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-5-201303050-00005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i39.5180"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12915"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.1180"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133515"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(93)90505-H"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306243282501"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04414.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.9409"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-7-200004040-00002"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/443891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:42:14Z","timestamp":1745430134000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000443891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/00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